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International Survey on Severe Acute Respiratory Syndrome Coronavirus 2 and Acute Pancreatitis Co-occurrence in Children.
Slae, Mordechai; Wilschanski, Michael; Sanjines, Elvi; Abu-El-Haija, Maisam; Sellers, Zachary M.
  • Slae M; From the Division of Pediatric Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Wilschanski M; From the Division of Pediatric Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Sanjines E; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA.
  • Sellers ZM; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA.
Pancreas ; 50(9): 1305-1309, 2021 10 01.
Article in English | MEDLINE | ID: covidwho-1621704
ABSTRACT

OBJECTIVES:

It is unknown to what extent coronavirus 2019 (COVID-19) may co-occur with acute pancreatitis (AP) in children and how their clinical course may differ from children with AP alone.

METHODS:

An online survey was sent to pediatric gastroenterologists to report on COVID-19 and AP cases from December 11, 2020, to February 26, 2021.

RESULTS:

From 72 respondents (20 countries, 5 continents), 22 cases of positive COVID-19 infection and AP were reported. Patients were predominantly White or Hispanic/Latinx (73%), female (68%), and adolescents (68%). For 86% of patients, this was their first episode of AP. Sixty-eight percent of positive COVID-19 tests were polymerase chain reaction based. There was significant morbidity; 60% required intensive care, 45% had multiorgan involvement, and 24% developed shock. Eleven percent had pancreatic necrosis. Abnormal clotting and systemic inflammatory laboratories were common (31%-92% and 93%, respectively). Median length of symptomatic pancreatitis recovery was 1.8× longer than AP without COVID-19.

CONCLUSIONS:

Coronavirus 2019 infection and AP co-occur primarily in children without a prior history of pancreatitis. Given the increased need for intensive care, multiorgan involvement, and potentially higher risk for pancreatic necrosis, pediatric providers should have a high level of suspicion for AP in children with COVID-19 infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancreatitis / COVID-19 / Multiple Organ Failure Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Young adult Language: English Journal: Pancreas Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: MPA.0000000000001923

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancreatitis / COVID-19 / Multiple Organ Failure Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Young adult Language: English Journal: Pancreas Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: MPA.0000000000001923