Your browser doesn't support javascript.
From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection.
Serviente, Corinna; Decker, Stephen T; Layec, Gwenael.
  • Serviente C; Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts.
  • Decker ST; Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, Massachusetts.
  • Layec G; Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts.
J Appl Physiol (1985) ; 132(3): 581-592, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1622106
ABSTRACT
The long-term sequelae of the coronavirus disease 2019 (COVID-19) are multifaceted and, besides the lungs, impact other organs and tissues, even in cases of mild infection. Along with commonly reported symptoms such as fatigue and dyspnea, a significant proportion of those with prior COVID-19 infection also exhibit signs of cardiac damage, muscle weakness, and ultimately, poor exercise tolerance. This review provides an overview of evidence indicating cardiac impairments and persistent endothelial dysfunction in the peripheral vasculature of those previously infected with COVID-19, irrespective of the severity of the acute phase of illness. In addition, V̇o2peak appears to be lower in convalescent patients, which may stem, in part, from alterations in O2 transport such as impaired diffusional O2 conductance. Together, the persistent multi-organ dysfunction induced by COVID-19 may set previously healthy individuals on a trajectory towards frailty and disease. Given the large proportion of individuals recovering from COVID-19, it is critically important to better understand the physical sequelae of COVID-19, the underlying biological mechanisms contributing to these outcomes, and the long-term effects on future disease risk. This review highlights relevant literature on the pathophysiology post-COVID-19 infection, gaps in the literature, and emphasizes the need for the development of evidence-based rehabilitation guidelines.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Appl Physiol (1985) Journal subject: Physiology Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Appl Physiol (1985) Journal subject: Physiology Year: 2022 Document Type: Article