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The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy.
Khezri, Mohammad Rafi; Varzandeh, Reza; Ghasemnejad-Berenji, Morteza.
  • Khezri MR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Sero Road, 5715799313, Urmia, Iran. Drmnkh76@gmail.com.
  • Varzandeh R; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Sero Road, 5715799313, Urmia, Iran.
  • Ghasemnejad-Berenji M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Sero Road, 5715799313, Urmia, Iran. ghasemnejad.m@umsu.ac.ir.
Cell Mol Biol Lett ; 27(1): 6, 2022 Jan 11.
Article in English | MEDLINE | ID: covidwho-1622208
ABSTRACT
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate. The majority of deaths in this disease are caused by ARDS (acute respiratory distress syndrome) followed by cytokine storm and coagulation complications. Although alterations in the level of the number of coagulation factors have been detected in samples from COVID-19 patients, the direct molecular mechanism which has been involved in this pathologic process has not been explored yet. The PI3K/AKT signaling pathway is an intracellular pathway which plays a central role in cell survival. Also, in recent years the association between this pathway and coagulopathies has been well clarified. Therefore, based on the evidence on over-activity of the PI3K/AKT signaling pathway in SARS-CoV-2 infection, in the current review, the probable role of this cellular pathway as a therapeutic target for the prevention of coagulation complications in patients with COVID-19 is discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Blood Coagulation Disorders / Signal Transduction / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Cell Mol Biol Lett Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: S11658-022-00308-W

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Blood Coagulation Disorders / Signal Transduction / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Cell Mol Biol Lett Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: S11658-022-00308-W