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Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans.
Rabalski, Lukasz; Kosinski, Maciej; Mazur-Panasiuk, Natalia; Szewczyk, Boguslaw; Bienkowska-Szewczyk, Krystyna; Kant, Ravi; Sironen, Tarja; Pyrc, Krzysztof; Grzybek, Maciej.
  • Rabalski L; Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
  • Kosinski M; Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
  • Mazur-Panasiuk N; Malopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
  • Szewczyk B; Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
  • Bienkowska-Szewczyk K; Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
  • Kant R; Department of Virology, University of Helsinki, Helsinki, Finland.
  • Sironen T; Department of Virology, University of Helsinki, Helsinki, Finland.
  • Pyrc K; Malopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland. Electronic address: k.a.pyrc@uj.edu.pl.
  • Grzybek M; Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Gdynia, Poland. Electronic address: maciej.grzybek@gumed.edu.pl.
Clin Microbiol Infect ; 28(3): 451.e1-451.e4, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1623323
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ABSTRACT

OBJECTIVES:

This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months.

METHODS:

Next-generation sequencing and a bioinformatic approach were applied to analyse the data.

RESULTS:

In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.

CONCLUSIONS:

Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Variants Limits: Animals / Humans Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.cmi.2021.12.001

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Variants Limits: Animals / Humans Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.cmi.2021.12.001