Massive Nonfatal Hydroxychloroquine Ingestion in a Pediatric Patient.
J Emerg Med
; 62(3): 332-336, 2022 03.
Article
in English
| MEDLINE | ID: covidwho-1624787
ABSTRACT
BACKGROUND:
Hydroxychloroquine overdose is rare but potentially lethal. Hydroxychloroquine overdose symptoms are characterized by central nervous system toxicity, cardiac toxicity, and hypokalemia. Recommended treatment consists of epinephrine, high-dose diazepam, and careful potassium repletion. Few pediatric hydroxychloroquine overdoses have been reported. CASE REPORT We describe a 14-year-old girl who ingested 10 g (172 mg/kg) of hydroxychloroquine. She developed tachycardia, hypotension, and hypokalemia. She was intubated and treated with diazepam and epinephrine infusions and potassium supplementation. Her serum hydroxychloroquine concentration obtained 10 h after ingestion was 13,000 ng/mL (reference range 500-2000 ng/mL). The patient made a full medical recovery. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS? Pediatric hydroxychloroquine overdoses are reported rarely, and the toxic and lethal doses of hydroxychloroquine ingestion have not been established. This case of a teenaged patient who ingested 10 g of hydroxychloroquine and survived provides additional information that may be used to help establish toxic and lethal doses of ingestion.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drug Overdose
/
Hypokalemia
Type of study:
Case report
/
Prognostic study
Limits:
Adolescent
/
Child
/
Female
/
Humans
Language:
English
Journal:
J Emerg Med
Journal subject:
Emergency Medicine
Year:
2022
Document Type:
Article
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