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Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19.
Apple, Alexandra C; Oddi, Alexis; Peluso, Michael J; Asken, Breton M; Henrich, Timothy J; Kelly, J Daniel; Pleasure, Samuel J; Deeks, Steven G; Allen, Isabel Elaine; Martin, Jeffrey N; Ndhlovu, Lishomwa C; Miller, Bruce L; Stephens, Melanie L; Hellmuth, Joanna.
  • Apple AC; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
  • Oddi A; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Peluso MJ; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
  • Asken BM; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Henrich TJ; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Kelly JD; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
  • Pleasure SJ; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Deeks SG; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Allen IE; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Martin JN; Institute for Global Health Sciences, University of California, San Francisco, San Francisco, California, USA.
  • Ndhlovu LC; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
  • Miller BL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Stephens ML; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Hellmuth J; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Ann Clin Transl Neurol ; 9(2): 221-226, 2022 02.
Article in English | MEDLINE | ID: covidwho-1624961
ABSTRACT
Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre-existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrospinal Fluid / Cognition / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Ann Clin Transl Neurol Year: 2022 Document Type: Article Affiliation country: Acn3.51498

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrospinal Fluid / Cognition / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Ann Clin Transl Neurol Year: 2022 Document Type: Article Affiliation country: Acn3.51498