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Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies.
Catalano, Alessia; Iacopetta, Domenico; Ceramella, Jessica; Scumaci, Domenica; Giuzio, Federica; Saturnino, Carmela; Aquaro, Stefano; Rosano, Camillo; Sinicropi, Maria Stefania.
  • Catalano A; Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70126 Bari, Italy.
  • Iacopetta D; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
  • Ceramella J; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
  • Scumaci D; Research Center on Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, 88100 Catanzaro, Italy.
  • Giuzio F; International PhD Programme 'Sciences', Department of Science, University of Basilicata, Viale dell'Ateneo Lucano n. 10, 85100 Potenza, Italy.
  • Saturnino C; Department of Science, University of Basilicata, 85100 Potenza, Italy.
  • Aquaro S; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
  • Rosano C; Proteomics and Mass Spectrometry Unit, IRCCS Policlinico San Martino, Largo Rosanna Benzi, 10, 16132 Genoa, Italy.
  • Sinicropi MS; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Molecules ; 27(3)2022 Jan 18.
Article in English | MEDLINE | ID: covidwho-1625062
ABSTRACT
Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, this phenomenon has increased both mortality and morbidity as a consequence of treatment failures and its incidence in healthcare costs. The large amounts of antibiotics used in human therapies, as well as for farm animals and even for fishes in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. It is not negligible that the ongoing COVID-19 pandemic may further contribute to antimicrobial resistance. In this paper, multidrug resistance and antimicrobial resistance are underlined, focusing on the therapeutic options to overcome these obstacles in drug treatments. Lastly, some recent studies on nanodrug delivery systems have been reviewed since they may represent a significant approach for overcoming resistance.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Resistance, Multiple / Drug Resistance, Neoplasm Type of study: Observational study Limits: Animals / Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27030616

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Resistance, Multiple / Drug Resistance, Neoplasm Type of study: Observational study Limits: Animals / Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27030616