Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19.
Nat Genet
; 54(2): 125-127, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1625297
ABSTRACT
The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
2',5'-Oligoadenylate Synthetase
/
RNA Splicing
/
Genetic Predisposition to Disease
/
Physical Chromosome Mapping
/
COVID-19
Type of study:
Prognostic study
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Nat Genet
Journal subject:
Genetics, Medical
Year:
2022
Document Type:
Article
Affiliation country:
S41588-021-00996-8
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