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Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021.
Kwok, Shirley Ll; Cheng, Samuel Ms; Leung, Jennifer Ns; Leung, Kathy; Lee, Cheuk-Kwong; Peiris, Js Malik; Wu, Joseph T.
  • Kwok SL; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Cheng SM; Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Hong Kong Special Administrative Region, China.
  • Leung JN; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Leung K; HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Lee CK; Centre for Immunology and Infection (C2i), Hong Kong Science Park, Hong Kong Special Administrative Region, China.
  • Peiris JM; Hong Kong Red Cross Blood Transfusion Service, Hospital Authority, Hong Kong Special Administrative Region, China.
  • Wu JT; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Euro Surveill ; 27(2)2022 01.
Article in English | MEDLINE | ID: covidwho-1625399
ABSTRACT
The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong's COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group's (n = 593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group's (n = 257) median antibody levels began to fall below the cut-offs 4 months after vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.ES.2022.27.2.2101197

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.ES.2022.27.2.2101197