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SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review.
Ledda, Caterina; Costantino, Claudio; Motta, Giuseppe; Cunsolo, Rosario; Stracquadanio, Patrizia; Liberti, Giuseppe; Maltezou, Helena C; Rapisarda, Venerando.
  • Ledda C; Occupational Medicine Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
  • Costantino C; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.
  • Motta G; Occupational Medicine Unit, "Garibaldi" Hospital of Catania, 95123 Catania, Italy.
  • Cunsolo R; Hospital Health Management, "G. Rodolico-San Marco" Polyclinic University Hospital, 95123 Catania, Italy.
  • Stracquadanio P; Occupational Medicine Unit, "G. Rodolico-San Marco" University Hospital, 95123 Catania, Italy.
  • Liberti G; Commissioner Office in Acta for the COVID-19 Emergency, Provincial Health Authority of Catania, 95123 Catania, Italy.
  • Maltezou HC; Directorate for Research, Studies and Documentation, National Public Health Organization, 15123 Athens, Greece.
  • Rapisarda V; Occupational Medicine Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Trop Med Infect Dis ; 7(1)2022 Jan 13.
Article in English | MEDLINE | ID: covidwho-1625412
ABSTRACT
The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used "Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*". The research was carried out utilizing the following databases SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ranging from 0.011 to 0.001 (per 100 individuals at risk). Our findings further support the published high effectiveness rates of mRNA vaccines in preventing SARS-CoV-2 infections among fully vaccinated HCP. Additional studies are needed to define the duration of the vaccine-induced protection among HCP.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Tropicalmed7010009

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Tropicalmed7010009