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Does Oxidative Stress Management Help Alleviation of COVID-19 Symptoms in Patients Experiencing Diabetes?
Paul, Alok K; Hossain, Md K; Mahboob, Tooba; Nissapatorn, Veeranoot; Wilairatana, Polrat; Jahan, Rownak; Jannat, Khoshnur; Bondhon, Tohmina A; Hasan, Anamul; de Lourdes Pereira, Maria; Rahmatullah, Mohammed.
  • Paul AK; School of Pharmacy and Pharmacology, University of Tasmania, Private Bag 26, Hobart, TAS 7001, Australia.
  • Hossain MK; Department of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
  • Mahboob T; Institute for Health and Sports, Victoria University, Melbourne, VIC 3011, Australia.
  • Nissapatorn V; World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
  • Wilairatana P; World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
  • Jahan R; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
  • Jannat K; Department of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
  • Bondhon TA; Department of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
  • Hasan A; Department of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
  • de Lourdes Pereira M; Department of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
  • Rahmatullah M; CICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.
Nutrients ; 14(2)2022 Jan 13.
Article in English | MEDLINE | ID: covidwho-1625635
ABSTRACT
Severe acute respiratory syndrome (SARS)-CoV-2 virus causes novel coronavirus disease 2019 (COVID-19) with other comorbidities such as diabetes. Diabetes is the most common cause of diabetic nephropathy, which is attributed to hyperglycemia. COVID-19 produces severe complications in people with diabetes mellitus. This article explains how SARS-CoV-2 causes more significant kidney damage in diabetic patients. Importantly, COVID-19 and diabetes share inflammatory pathways of disease progression. SARS-CoV-2 binding with ACE-2 causes depletion of ACE-2 (angiotensin-converting enzyme 2) from blood vessels, and subsequently, angiotensin-II interacts with angiotensin receptor-1 from vascular membranes that produce NADPH (nicotinamide adenine dinucleotide hydrogen phosphate) oxidase, oxidative stress, and constriction of blood vessels. Since diabetes and COVID-19 can create oxidative stress, we hypothesize that COVID-19 with comorbidities such as diabetes can synergistically increase oxidative stress leading to end-stage renal failure and death. Antioxidants may therefore prevent renal damage-induced death by inhibiting oxidative damage and thus can help protect people from COVID-19 related comorbidities. A few clinical trials indicated how effective the antioxidant therapy is against improving COVID-19 symptoms, based on a limited number of patients who experienced COVID-19. In this review, we tried to understand how effective antioxidants (such as vitamin D and flavonoids) can act as food supplements or therapeutics against COVID-19 with diabetes as comorbidity based on recently available clinical, preclinical, or in silico studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / Diabetic Nephropathies / COVID-19 / Antioxidants Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14020321

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / Diabetic Nephropathies / COVID-19 / Antioxidants Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14020321