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Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic Manifestations.
Ravid, Jonathan D; Leiva, Orly; Chitalia, Vipul C.
  • Ravid JD; Internal Medicine Residency Program, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Leiva O; Division of Cardiology, Department of Medicine, New York University Langone Health, New York, NY 10016, USA.
  • Chitalia VC; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02139, USA.
Cells ; 11(2)2022 01 17.
Article in English | MEDLINE | ID: covidwho-1625673
ABSTRACT
Acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continues to be a worldwide public health crisis. Among the several severe manifestations of this disease, thrombotic processes drive the catastrophic organ failure and mortality in these patients. In addition to a well-established cytokine storm associated with the disease, perturbations in platelets, endothelial cells, and the coagulation system are key in triggering systemic coagulopathy, involving both the macro- and microvasculatures of different organs. Of the several mechanisms that might contribute to dysregulation of these cells following SARS-CoV-2 infection, the current review focuses on the role of activated Janus kinase (JAK) signaling in augmenting thrombotic processes and organ dysfunction. The review concludes with presenting the current understanding and emerging controversies concerning the potential therapeutic applications of JAK inhibitors for ameliorating the inflammation-thrombosis phenotype in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Signal Transduction / Endothelial Cells / Janus Kinases / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11020306

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Signal Transduction / Endothelial Cells / Janus Kinases / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11020306