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Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants.
Reynolds, Catherine J; Gibbons, Joseph M; Pade, Corinna; Lin, Kai-Min; Sandoval, Diana Muñoz; Pieper, Franziska; Butler, David K; Liu, Siyi; Otter, Ashley D; Joy, George; Menacho, Katia; Fontana, Marianna; Smit, Angelique; Kele, Beatrix; Cutino-Moguel, Teresa; Maini, Mala K; Noursadeghi, Mahdad; Brooks, Tim; Semper, Amanda; Manisty, Charlotte; Treibel, Thomas A; Moon, James C; McKnight, Áine; Altmann, Daniel M; Boyton, Rosemary J.
  • Reynolds CJ; Department of Infectious Disease, Imperial College London, London, UK.
  • Gibbons JM; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Pade C; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Lin KM; Department of Infectious Disease, Imperial College London, London, UK.
  • Sandoval DM; Department of Infectious Disease, Imperial College London, London, UK.
  • Pieper F; Department of Infectious Disease, Imperial College London, London, UK.
  • Butler DK; Department of Infectious Disease, Imperial College London, London, UK.
  • Liu S; Department of Infectious Disease, Imperial College London, London, UK.
  • Otter AD; UK Health Security Agency, Porton Down, UK.
  • Joy G; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Menacho K; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Fontana M; Royal Free London NHS Foundation Trust, London, UK.
  • Smit A; Royal Free London NHS Foundation Trust, London, UK.
  • Kele B; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Cutino-Moguel T; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Maini MK; Division of Infection and Immunity, University College London, London, UK.
  • Noursadeghi M; Division of Infection and Immunity, University College London, London, UK.
  • Brooks T; UK Health Security Agency, Porton Down, UK.
  • Semper A; UK Health Security Agency, Porton Down, UK.
  • Manisty C; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Treibel TA; Institute of Cardiovascular Science, University College London, London, UK.
  • Moon JC; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • McKnight Á; St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Altmann DM; Institute of Cardiovascular Science, University College London, London, UK.
Science ; 375(6577): 183-192, 2022 Jan 14.
Article in English | MEDLINE | ID: covidwho-1625678
ABSTRACT
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting strain on downstream immunity to heterologous variants of concern (VOCs) is unknown. Studying a longitudinal healthcare worker cohort, we found that after three antigen exposures (infection plus two vaccine doses), S1 antibody, memory B cells, and heterologous neutralization of B.1.351, P.1, and B.1.617.2 plateaued, whereas B.1.1.7 neutralization and spike T cell responses increased. Serology using the Wuhan Hu-1 spike receptor binding domain poorly predicted neutralizing immunity against VOCs. Neutralization potency against VOCs changed with heterologous virus encounter and number of antigen exposures. Neutralization potency fell differentially depending on targeted VOCs over the 5 months from the second vaccine dose. Heterologous combinations of spike encountered during infection and vaccination shape subsequent cross-protection against VOC, with implications for future-proof next-generation vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / BNT162 Vaccine Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Adult / Female / Humans / Male Language: English Journal: Science Year: 2022 Document Type: Article Affiliation country: Science.abm0811

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / BNT162 Vaccine Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Adult / Female / Humans / Male Language: English Journal: Science Year: 2022 Document Type: Article Affiliation country: Science.abm0811