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Presence of Recombinant Bat Coronavirus GCCDC1 in Cambodian Bats.
Zhu, Feng; Duong, Veasna; Lim, Xiao Fang; Hul, Vibol; Chawla, Tanu; Keatts, Lucy; Goldstein, Tracey; Hassanin, Alexandre; Tu, Vuong Tan; Buchy, Philippe; Sessions, October M; Wang, Lin-Fa; Dussart, Philippe; Anderson, Danielle E.
  • Zhu F; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Duong V; Virology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh 120210, Cambodia.
  • Lim XF; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Hul V; Virology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh 120210, Cambodia.
  • Chawla T; Unité des Virus Émergents, (UVÉ: Aix-Marseille Univ-IRD 190-INSERM 1207), 13005 Marseille, France.
  • Keatts L; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Goldstein T; Wildlife Conservation Society, Health Program, Bronx, NY 10460, USA.
  • Hassanin A; One Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
  • Tu VT; One Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
  • Buchy P; Institut de Systématique, Évolution, Biodiversité, Sorbonne Université, MNHN, CNRS, EPHE, UA, 75005 Paris, France.
  • Sessions OM; Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, No. 18, Hoang Quoc Viet Road, Cau Giay District, Hanoi 10072, Vietnam.
  • Wang LF; Virology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh 120210, Cambodia.
  • Dussart P; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Anderson DE; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Viruses ; 14(2)2022 01 18.
Article in English | MEDLINE | ID: covidwho-1625960
ABSTRACT
Bats have been recognized as an exceptional viral reservoir, especially for coronaviruses. At least three bat zoonotic coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have been shown to cause severe diseases in humans and it is expected more will emerge. One of the major features of CoVs is that they are all highly prone to recombination. An extreme example is the insertion of the P10 gene from reoviruses in the bat CoV GCCDC1, first discovered in Rousettus leschenaultii bats in China. Here, we report the detection of GCCDC1 in four different bat species (Eonycteris spelaea, Cynopterus sphinx, Rhinolophus shameli and Rousettus sp.) in Cambodia. This finding demonstrates a much broader geographic and bat species range for this virus and indicates common cross-species transmission. Interestingly, one of the bat samples showed a co-infection with an Alpha CoV most closely related to RsYN14, a virus recently discovered in the same genus (Rhinolophus) of bat in Yunnan, China, 2020. Taken together, our latest findings highlight the need to conduct active surveillance in bats to assess the risk of emerging CoVs, especially in Southeast Asia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Recombination, Genetic / Disease Reservoirs / Chiroptera / Coronaviridae / Coronaviridae Infections / Phylogeography Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Year: 2022 Document Type: Article Affiliation country: V14020176

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Recombination, Genetic / Disease Reservoirs / Chiroptera / Coronaviridae / Coronaviridae Infections / Phylogeography Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Year: 2022 Document Type: Article Affiliation country: V14020176