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Assessment of CD39 expression in regulatory T-cell subsets by disease severity in adult and juvenile COVID-19 cases.
Simsek, Abdurrahman; Kizmaz, Muhammed A; Cagan, Eren; Dombaz, Fatma; Tezcan, Gulcin; Asan, Ali; Demir, H Ibrahim; Bal, S Haldun; Ermis, Digdem Y; Dilektasli, Asli G; Kazak, Esra; Akalin, E Halis; Oral, H Barbaros; Budak, Ferah.
  • Simsek A; Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
  • Kizmaz MA; Department of Immunology, Health Science Institute, Bursa Uludag University, Bursa, Turkey.
  • Cagan E; Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
  • Dombaz F; Department of Immunology, Health Science Institute, Bursa Uludag University, Bursa, Turkey.
  • Tezcan G; Department of Pediatric Infectious Diseases, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
  • Asan A; Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
  • Demir HI; Department of Immunology, Health Science Institute, Bursa Uludag University, Bursa, Turkey.
  • Bal SH; Department of Fundamental Science, Faculty of Dentistry, Bursa Uludag University, Bursa, Turkey.
  • Ermis DY; Department of Infectious Diseases and Clinical Microbiology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
  • Dilektasli AG; Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
  • Kazak E; Department of Immunology, Health Science Institute, Bursa Uludag University, Bursa, Turkey.
  • Akalin EH; Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
  • Oral HB; Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
  • Budak F; Department of Chest Diseases, Bursa Uludag University, Bursa, Turkey.
J Med Virol ; 94(5): 2089-2101, 2022 05.
Article in English | MEDLINE | ID: covidwho-1626431
ABSTRACT
COVID-19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID-19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10-color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39+ Tregs increased with disease severity. In contrast, CD39+ Tregs were decreased in juvenile patients in an age-dependent manner. Overall, our study reveals an interesting profile of CD39-expressing Tregs in adult and juvenile cases of COVID-19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID-19 cases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Apyrase / T-Lymphocytes, Regulatory / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27593

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Apyrase / T-Lymphocytes, Regulatory / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27593