Epidemiology of Acute Heart Failure in Critically Ill Patients With COVID-19: An Analysis From the Critical Care Cardiology Trials Network.
J Card Fail
; 28(4): 675-681, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1627205
ABSTRACT
BACKGROUND:
Acute heart failure (HF) is an important complication of coronavirus disease 2019 (COVID-19) and has been hypothesized to relate to inflammatory activation.METHODS:
We evaluated consecutive intensive care unit (ICU) admissions for COVID-19 across 6 centers in the Critical Care Cardiology Trials Network, identifying patients with vs without acute HF. Acute HF was subclassified as de novo vs acute-on-chronic, based on the absence or presence of prior HF. Clinical features, biomarker profiles and outcomes were compared.RESULTS:
Of 901 admissions to an ICU due to COVID-19, 80 (8.9%) had acute HF, including 18 (2.0%) with classic cardiogenic shock (CS) and 37 (4.1%) with vasodilatory CS. The majority (nâ¯=â¯45) were de novo HF presentations. Compared to patients without acute HF, those with acute HF had higher cardiac troponin and natriuretic peptide levels and similar inflammatory biomarkers; patients with de novo HF had the highest cardiac troponin levels. Notably, among patients critically ill with COVID-19, illness severity (median Sequential Organ Failure Assessment, 8 [IQR, 5-10] vs 6 [4-9]; Pâ¯=â¯0.025) and mortality rates (43.8% vs 32.4%; Pâ¯=â¯0.040) were modestly higher in patients with vs those without acute HF.CONCLUSIONS:
Among patients critically ill with COVID-19, acute HF is distinguished more by biomarkers of myocardial injury and hemodynamic stress than by biomarkers of inflammation.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cardiology
/
COVID-19
/
Heart Failure
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Card Fail
Journal subject:
Cardiology
Year:
2022
Document Type:
Article
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