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Hepatitis E in Bangladesh: Insights From a National Serosurvey.
Azman, Andrew S; Paul, Kishor Kumar; Bhuiyan, Taufiqur Rahman; Koyuncu, Aybüke; Salje, Henrik; Qadri, Firdausi; Gurley, Emily S.
  • Azman AS; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Paul KK; Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Bhuiyan TR; icddr,b, Dhaka, Bangladesh.
  • Koyuncu A; icddr,b, Dhaka, Bangladesh.
  • Salje H; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Qadri F; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Gurley ES; University of Cambridge, Cambridge, United Kingdom.
J Infect Dis ; 224(12 Suppl 2): S805-S812, 2021 12 20.
Article in English | MEDLINE | ID: covidwho-1627209
ABSTRACT

BACKGROUND:

Hepatitis E virus (HEV) genotypes 1 and 2 are a major cause of avoidable morbidity and mortality in South Asia. Despite the high risk of death among infected pregnant women, scarce incidence data has been a contributing factor to global policy recommendations against the introduction of licensed hepatitis E vaccines, one of the only effective prevention tools.

METHODS:

We tested serum from a nationally representative serosurvey in Bangladesh for anti-HEV immunoglobulin G and estimated seroprevalence. We used Bayesian geostatistical models to generate high-resolution maps of seropositivity and examined variability in seropositivity by individual-level, household-level, and community-level risk factors using spatial logistic regression.

RESULTS:

We tested serum samples from 2924 individuals from 70 communities representing all divisions of Bangladesh and estimated a national seroprevalence of 20% (95% confidence interval [CI], 17%-24%). Seropositivity increased with age and male sex (odds ratio, 2.2 male vs female; 95% CI, 1.8-2.8). Community-level seroprevalence ranged widely (0-78%) with higher seroprevalence in urban areas, including Dhaka, with a 3.0-fold (95% credible interval, 2.3-3.7) higher seroprevalence than the rest of the country.

CONCLUSIONS:

Hepatitis E infections are common throughout Bangladesh. Strengthening surveillance for hepatitis E, especially in urban areas, can provide additional evidence to appropriately target interventions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Hepatitis Antibodies / Hepatitis E virus / Hepatitis E Type of study: Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Hepatitis Antibodies / Hepatitis E virus / Hepatitis E Type of study: Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis