Intermittent theta burst stimulation over the parietal cortex has a significant neural effect on working memory.
Hum Brain Mapp
; 43(3): 1076-1086, 2022 02 15.
Article
in English
| MEDLINE | ID: covidwho-1627415
ABSTRACT
The crucial role of the parietal cortex in working memory (WM) storage has been identified by fMRI studies. However, it remains unknown whether repeated parietal intermittent theta-burst stimulation (iTBS) can improve WM. In this within-subject randomized controlled study, under the guidance of fMRI-identified parietal activation in the left hemisphere, 22 healthy adults received real and sham iTBS sessions (five consecutive days, 600 pulses per day for each session) with an interval of 9 months between the two sessions. Electroencephalography signals of each subject before and after both iTBS sessions were collected during a change detection task. Changes in contralateral delay activity (CDA) and K-score were then calculated to reflect neural and behavioral WM improvement. Repeated-measures ANOVA suggested that real iTBS increased CDA more than the sham one (p = .011 for iTBS effect). Further analysis showed that this effect was more significant in the left hemisphere than in the right hemisphere (p = .029 for the hemisphere-by-iTBS interaction effect). Pearson correlation analyses showed significant correlations for two conditions between CDA changes in the left hemisphere and K score changes (ps <.05). In terms of the behavioral results, significant K score changes after real iTBS were observed for two conditions, but a repeated-measures ANOVA showed a nonsignificant main effect of iTBS (p = .826). These results indicate that the current iTBS protocol is a promising way to improve WM capability based on the neural indicator (CDA) but further optimization is needed to produce a behavioral effect.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parietal Lobe
/
Psychomotor Performance
/
Electroencephalography
/
Transcranial Magnetic Stimulation
/
Memory, Short-Term
Type of study:
Cohort study
/
Experimental Studies
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Prognostic study
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Randomized controlled trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Young adult
Language:
English
Journal:
Hum Brain Mapp
Journal subject:
Brain
Year:
2022
Document Type:
Article
Affiliation country:
Hbm.25708
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