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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons.
Liu, Jamin; Laurie, Matthew T; Rubio, Luis; Vazquez, Sara E; Sunshine, Sara; Mitchell, Anthea M; Hapte-Selassie, Matthias; Mann, Sabrina A; Pilarowski, Genay; Black, Douglas; Marquez, Carina; Rojas, Susana; Lionakis, Michail S; Petersen, Maya; Whitman, Jeffrey D; Jain, Vivek; Anderson, Mark; Havlir, Diane; DeRisi, Joseph.
  • Liu J; University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, California, USA.
  • Laurie MT; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Rubio L; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Vazquez SE; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Sunshine S; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Mitchell AM; Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California, USA.
  • Hapte-Selassie M; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Mann SA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Pilarowski G; Chan Zuckerberg Biohub, San Francisco, California, USA.
  • Black D; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Marquez C; Chan Zuckerberg Biohub, San Francisco, California, USA.
  • Rojas S; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
  • Lionakis MS; Chan Zuckerberg Biohub, San Francisco, California, USA.
  • Petersen M; The Public Health Company, Oakland, California, USA.
  • Whitman JD; Unidos en Salud, San Francisco, California, USA.
  • Jain V; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Anderson M; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Havlir D; Unidos en Salud, San Francisco, California, USA.
  • DeRisi J; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Clin Infect Dis ; 75(1): e303-e306, 2022 08 24.
Article in English | MEDLINE | ID: covidwho-2017815
ABSTRACT
While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid