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Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.
Zhou, Jie; Peacock, Thomas P; Brown, Jonathan C; Goldhill, Daniel H; Elrefaey, Ahmed M E; Penrice-Randal, Rebekah; Cowton, Vanessa M; De Lorenzo, Giuditta; Furnon, Wilhelm; Harvey, William T; Kugathasan, Ruthiran; Frise, Rebecca; Baillon, Laury; Lassaunière, Ria; Thakur, Nazia; Gallo, Giulia; Goldswain, Hannah; Donovan-Banfield, I'ah; Dong, Xiaofeng; Randle, Nadine P; Sweeney, Fiachra; Glynn, Martha C; Quantrill, Jessica L; McKay, Paul F; Patel, Arvind H; Palmarini, Massimo; Hiscox, Julian A; Bailey, Dalan; Barclay, Wendy S.
  • Zhou J; Department of Infectious Disease, Imperial College London, London, UK.
  • Peacock TP; Department of Infectious Disease, Imperial College London, London, UK.
  • Brown JC; Department of Infectious Disease, Imperial College London, London, UK.
  • Goldhill DH; Department of Infectious Disease, Imperial College London, London, UK.
  • Elrefaey AME; The Pirbright Institute, Woking, Surrey, UK.
  • Penrice-Randal R; Institute of Infection, Veterinary and Ecology Sciences, University of Liverpool, Liverpool, UK.
  • Cowton VM; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • De Lorenzo G; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Furnon W; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Harvey WT; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Kugathasan R; Department of Infectious Disease, Imperial College London, London, UK.
  • Frise R; Department of Infectious Disease, Imperial College London, London, UK.
  • Baillon L; Department of Infectious Disease, Imperial College London, London, UK.
  • Lassaunière R; Virus & Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
  • Thakur N; The Pirbright Institute, Woking, Surrey, UK; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Gallo G; The Pirbright Institute, Woking, Surrey, UK.
  • Goldswain H; Institute of Infection, Veterinary and Ecology Sciences, University of Liverpool, Liverpool, UK.
  • Donovan-Banfield I; Institute of Infection, Veterinary and Ecology Sciences, University of Liverpool, Liverpool, UK.
  • Dong X; Institute of Infection, Veterinary and Ecology Sciences, University of Liverpool, Liverpool, UK.
  • Randle NP; Institute of Infection, Veterinary and Ecology Sciences, University of Liverpool, Liverpool, UK.
  • Sweeney F; Department of Infectious Disease, Imperial College London, London, UK.
  • Glynn MC; Department of Infectious Disease, Imperial College London, London, UK.
  • Quantrill JL; Department of Infectious Disease, Imperial College London, London, UK.
  • McKay PF; Department of Infectious Disease, Imperial College London, London, UK.
  • Patel AH; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Palmarini M; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Hiscox JA; Institute of Infection, Veterinary and Ecology Sciences, University of Liverpool, Liverpool, UK; Infectious Diseases Horizontal Technology Centre (ID HTC), A(∗)STAR, Singapore, Singapore.
  • Bailey D; The Pirbright Institute, Woking, Surrey, UK.
  • Barclay WS; Department of Infectious Disease, Imperial College London, London, UK. Electronic address: w.barclay@imperial.ac.uk.
Cell Rep ; 38(6): 110344, 2022 02 08.
Article in English | MEDLINE | ID: covidwho-1639571
ABSTRACT
SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs, and farmed mink. Since the start of the 2019 pandemic, several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T all specifically adapt SARS-CoV-2 to use mustelid ACE2. Furthermore, we risk assess these mutations and conclude mink-adapted viruses are unlikely to pose an increased threat to humans, as Y453F attenuates the virus replication in human cells and all three mink adaptations have minimal antigenic impact. Finally, we show that certain SARS-CoV-2 variants emerging from circulation in humans may naturally have a greater propensity to infect mustelid hosts and therefore these species should continue to be surveyed for reverse zoonotic infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adaptation, Biological / Viral Zoonoses / SARS-CoV-2 Type of study: Observational study / Prognostic study Topics: Variants Limits: Animals / Humans Language: English Journal: Cell Rep Year: 2022 Document Type: Article Affiliation country: J.CELREP.2022.110344

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adaptation, Biological / Viral Zoonoses / SARS-CoV-2 Type of study: Observational study / Prognostic study Topics: Variants Limits: Animals / Humans Language: English Journal: Cell Rep Year: 2022 Document Type: Article Affiliation country: J.CELREP.2022.110344