Chronic kidney disease as a predictor of in-hospital mortality in Coronavirus Disease 2019 (COVID-19) patients

ABSTRACT

Introduction. Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 (COVID-19) patients considering its high prevalence. We aimed to figured out the relationship between CKD and COVID-19 mortality in the present study. Methods. In total, 116 CKD patients (eGFR lower than 60 mL/min/1.73 m2) and 147 control subjects confirmed with COVID-19 were studied. Data regarding demographics, sign and symptoms, laboratory findings and chest computed tomography were collected. Association between CKD and in-hospital mortality were analyzed using logistic regression models adjusted for confounders. Results. Mortality rate was significantly higher in CKD than non-CKD (30.17 vs. 4.76, P < 0.001) COVID-19 patients. Multivariate logistic regression showed that CKD was significantly correlated with in-hospital mortality in the total sample (OR = 8.64, CI 3.67-20.35) and gender subgroups (females OR = 4.77, CI 1.38-16.40, males OR = 13.43, CI 3.85-46.87) (P < 0.05) of COVID-19 patients in the crud model. Whereas, the correlation did not remain significant in the fully adjusted model in the total sample (OR = 1.70, CI 0.35-8.19) and gender subgroups (females OR =1.07 CI 0.06-19.82, males OR = 0.87, CI 0.07-10.33) (P > 0.05) of COVID-19 patients. Conclusion. The present study suggested an independent association between CKD and in-hospital mortality in COVID-19 patients. Therefore, more intensive surveillance of COVID-19 patients with CKD is to be warranted.