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Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms.
Capozza, Paolo; Pratelli, Annamaria; Camero, Michele; Lanave, Gianvito; Greco, Grazia; Pellegrini, Francesco; Tempesta, Maria.
  • Capozza P; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
  • Pratelli A; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
  • Camero M; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
  • Lanave G; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
  • Greco G; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
  • Pellegrini F; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
  • Tempesta M; Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.
Animals (Basel) ; 11(12)2021 Dec 14.
Article in English | MEDLINE | ID: covidwho-1628466
ABSTRACT
Over time, feline viruses have acquired elaborateopportunistic properties, making their infections particularly difficult to prevent and treat. Feline coronavirus (FCoV) and feline herpesvirus-1 (FeHV-1), due to the involvement of host genetic factors and immune mechanisms in the development of the disease and more severe forms, are important examples of immune evasion of the host's innate immune response by feline viruses.It is widely accepted that the innate immune system, which providesan initial universal form of the mammalian host protection from infectious diseases without pre-exposure, plays an essential role in determining the outcome of viral infection.The main components of this immune systembranchare represented by the internal sensors of the host cells that are able to perceive the presence of viral component, including nucleic acids, to start and trigger the production of first type interferon and to activate the cytotoxicity by Natural Killercells, often exploited by viruses for immune evasion.In this brief review, we providea general overview of the principal tools of innate immunity, focusing on the immunologic escape implemented byFCoVand FeHV-1 duringinfection.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Ani11123548

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Ani11123548