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Gender based difference in outcomes of myocardial injury in covid-19 positive patients in low to middle income country
Circulation ; 144(SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1629419
ABSTRACT

Introduction:

Myocardial injury is associated with poor outcomes in COVID-19 positive patients. We have limited data about gender-based differences, in terms of outcomes in COVID-19 associated myocardial injury, especially from low to middle income country.

Hypothesis:

Myocardial injury in COVID-19 positive patients has the same impact on outcomes in either gender.

Methods:

We prospectively collected data of patients admitted with COVID 19 (nasopharyngeal PCR positive) and myocardial injury (hsTrop I>99th percentile) at Aga Khan University Hospital (AKUH), Karachi, Pakistan from 26 Feburary'2020 to 26 November'2020. Both genders were compared in terms of presentation, complications, and mortality. Calculations were done separately for each variable between two groups keeping the significant criteria of p-value less than or equal to 0.05.

Result:

Among 171 patients fulfilling inclusion criteria, 28.07% (n=48) were female and 72% (n=123) were male. Baseline demographics demonstrated that hypertension was significantly high among females as compared to male patients (87.5% Female vs 65% Male, p=0.004). During the hospital stay, the need for supplemental oxygen, Noninvasive ventilation, and mechanical ventilation was significantly higher in males compared to females. A statistically non-significant trend towards increased mortality was noted in males.

Conclusion:

Our study signifies that COVID-19 associated myocardial injury in males is associated with worse hospital course as compare to females. The length of hospital stay, complications such as ARDS, and requirement of invasive and non-invasive ventilatory support were higher in males as compared to females. Further studies evaluating the cause of disparate hospital course based on gender are warranted.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Circulation Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Circulation Year: 2021 Document Type: Article