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Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study.
Congiu, T; Fanni, D; Piras, M; Gerosa, C; Cau, F; Barcellona, D; D'Aloja, E; Demontis, R; Chighine, A; Nioi, M; Coni, P; Ravarino, A; Cerrone, G; Aimola, V; Botta, C; Scano, A; Orrù, G; Coghe, F; Van Eyken, P; La Nasa, G; Saba, L; Suri, J S; Faa, G; Marongiu, F.
  • Congiu T; Division of Pathology, Department of Medical Sciences and Public Health, AOU of Cagliari, University of Cagliari, Cagliari, Italy. daniela.fanni@unica.it.
Eur Rev Med Pharmacol Sci ; 26(1): 270-277, 2022 01.
Article in English | MEDLINE | ID: covidwho-1631285
ABSTRACT
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare new syndrome occurring after the ChAdOx1 nCoV-19 vaccine immunization. Patients with VITT are characterized by a variable clinical presentation, likewise also the outcome of these patients is very variable. Here we report the lung ultrastructural findings in the course of VITT of a 58-year-old male patient. Alveoli were mainly dilated, irregular in shape, and occupied by a reticular network of fibrin, while interalveolar septa appeared thickened. The proliferation of small capillaries gave rise to plexiform structures and pulmonary capillary hemangiomatosis-like features. Near the alveoli occupied by a dense fibrin network, the medium-sized arteries showed a modified wall and an intraluminal thrombus. This scenario looks quite similar to that found during COVID-19, where the lungs suffer from the attack of the antigen-antibodies complexes and the virus respectively. In both diseases, the final outcome is a severe inflammation, activation of the haemostatic system and fibrinolysis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / Purpura, Thrombocytopenic, Idiopathic / Lung Injury Type of study: Diagnostic study Topics: Vaccines Limits: Humans / Male / Middle aged Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2022 Document Type: Article Affiliation country: Eurrev_202201_27777

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / Purpura, Thrombocytopenic, Idiopathic / Lung Injury Type of study: Diagnostic study Topics: Vaccines Limits: Humans / Male / Middle aged Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2022 Document Type: Article Affiliation country: Eurrev_202201_27777