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Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic, Pneumonia, and Severe Disease Caused by the Delta Variant: Real World Study and Evidence - China, 2021.
Wu, Dan; Zhang, Yanyang; Tang, Lin; Wang, Fuzhen; Ye, Ying; Ma, Chao; Zheng, Hui; Yu, Wenzhou; Cao, Lei; Song, Yifan; Reyimu, Abuduwaili; Zhang, Xiaoxiao; Wang, Haifeng; Nie, Yifei; Lu, Mingxia; Qi, Muge; Li, Jun; Wang, Ruolin; Yang, Kaichao; Wang, Changshuang; Rodewald, Lawrence Everett; Gao, Geroge Fu; An, Zhijie; Yin, Zundong.
  • Wu D; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Zhang Y; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Tang L; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Wang F; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Ye Y; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Ma C; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Zheng H; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Yu W; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Cao L; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Song Y; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Reyimu A; Akesu Prefectural Center for Disease Control and Prevention, Akesu, Xinjiang Uygur Autonomous Region, China.
  • Zhang X; China Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing, China.
  • Wang H; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Nie Y; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Lu M; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Qi M; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Li J; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Wang R; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Yang K; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Wang C; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Rodewald LE; Henan Provincial Disease Control and Prevention, Zhengzhou, Henan, China.
  • Gao GF; Chinese Center for Disease Control and Prevention, Beijing, China.
  • An Z; Chinese Center for Disease Control and Prevention, Beijing, China.
  • Yin Z; Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC Wkly ; 4(4): 57-65, 2022 Jan 28.
Article in English | MEDLINE | ID: covidwho-1631490
ABSTRACT
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? Effectiveness of China's 2 inactivated vaccines (BBIBP-CorV and CoronaVac) against pre-Delta severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants ranged from 47% to over 90%, depending on the clinical endpoint, and with greater effectiveness against more severe coronavirus disease 2019 (COVID-19). During an outbreak in Guangdong, inactivated vaccine effectiveness (VE) against the Delta variant was 70% for symptomatic infection and 100% for severe COVID-19. However, separate or combined VE estimates for the two inactivated vaccines against Delta are not available. WHAT IS ADDED BY THIS REPORT? In an outbreak that started in a hospital, VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant were 51%, 61%, and 82%. Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%. VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar, and partial vaccination was ineffective. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant. Completion of the completed primary vaccination with two doses is necessary for protection from Delta.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Language: English Journal: China CDC Wkly Year: 2022 Document Type: Article Affiliation country: Ccdcw2022.009

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Language: English Journal: China CDC Wkly Year: 2022 Document Type: Article Affiliation country: Ccdcw2022.009