Your browser doesn't support javascript.
High prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort study.
Díaz, Luis Antonio; García-Salum, Tamara; Fuentes-López, Eduardo; Reyes, Diego; Ortiz, Javier; Chahuan, Javier; Levican, Jorge; Almonacid, Leonardo I; Valenzuela, Gonzalo H; Serrano, Eileen; Budnik, Sigall; Gandara, Vicente; Gallardo, Andrea; Seydewitz, María Francisca; Ferrés, Marcela; Cofré, Colomba; Álvarez, Manuel; Pavez, Carolina; Candia, Roberto; Monrroy, Hugo; Espino, Alberto; Rada, Gabriel; Ortiz, Luis; Valderrama, Sebastián; Salinas, Erick; Toro, Adriana; Ortega, Marcos; Pizarro, Margarita; Medina, Rafael A; Riquelme, Arnoldo.
  • Díaz LA; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • García-Salum T; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Fuentes-López E; Department of Health Sciences, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Reyes D; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Ortiz J; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Chahuan J; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Levican J; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Almonacid LI; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Valenzuela GH; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Serrano E; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Budnik S; School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Gandara V; School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Gallardo A; School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Seydewitz MF; School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Ferrés M; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Cofré C; Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Álvarez M; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Pavez C; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Candia R; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Monrroy H; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Espino A; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Rada G; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile; Epistemonikos Foundation, Santiago, Chile.
  • Ortiz L; Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Valderrama S; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Salinas E; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Toro A; Pediatric Service, Clínica UC San Carlos, Red Salud UC Christus, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Ortega M; Department of Intensive Care Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Respiratory Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Pizarro M; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Medina RA; Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: rmedinai@uc.cl.
  • Riquelme A; Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Health Sciences, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: a.riquelme.perez@gmail.com.
Gastroenterol Hepatol ; 45(8): 593-604, 2022 Oct.
Article in English, Spanish | MEDLINE | ID: covidwho-1631719
ABSTRACT

OBJECTIVES:

To 1. Describe the frequency of viral RNA detection in stools in a cohort of patients infected with SARS-CoV-2, and 2. Perform a systematic review to assess the clearance time in stools of SARS-CoV-2.

METHODS:

We conducted a prospective cohort study in two centers between March and May 2020. We included SARS-CoV-2 infected patients of any age and severity. We collected seriated nasopharyngeal swabs and stool samples to detect SARS-CoV-2. After, we performed a systematic review of the prevalence and clearance of SARS-CoV-2 in stools (PROSPERO-ID CRD42020192490). We estimated prevalence using a random-effects model. We assessed clearance time by using Kaplan-Meier curves.

RESULTS:

We included 32 patients; mean age was 43.7±17.7 years, 43.8% were female, and 40.6% reported gastrointestinal symptoms. Twenty-five percent (8/32) of patients had detectable viral RNA in stools. The median clearance time in stools of the cohort was 11[10-15] days. Systematic review included 30 studies (1392 patients) with stool samples. Six studies were performed in children and 55% were male. The pooled prevalence of viral detection in stools was 34.6% (twenty-four studies, 1393 patients; 95%CI25.4-45.1); heterogeneity was high (I291.2%, Q208.6; p≤0.001). A meta-regression demonstrates an association between female-gender and lower presence in stools (p=0.004). The median clearance time in stools was 22 days (nineteen studies, 140 patients; 95%CI19-25). After 34 days, 19.9% (95%CI11.3-29.7) of patients have a persistent detection in stools.

CONCLUSIONS:

Detection of SARS-CoV-2 in stools is a frequent finding. The clearance of SARS-CoV-2 in stools is prolonged and it takes longer than nasopharyngeal secretions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adult / Child / Female / Humans / Male / Middle aged Language: English / Spanish Journal: Gastroenterol Hepatol Year: 2022 Document Type: Article Affiliation country: J.gastrohep.2021.12.009

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adult / Child / Female / Humans / Male / Middle aged Language: English / Spanish Journal: Gastroenterol Hepatol Year: 2022 Document Type: Article Affiliation country: J.gastrohep.2021.12.009