High prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort study.
Gastroenterol Hepatol
; 45(8): 593-604, 2022 Oct.
Article
in English, Spanish
| MEDLINE | ID: covidwho-1631719
ABSTRACT
OBJECTIVES:
To 1. Describe the frequency of viral RNA detection in stools in a cohort of patients infected with SARS-CoV-2, and 2. Perform a systematic review to assess the clearance time in stools of SARS-CoV-2.METHODS:
We conducted a prospective cohort study in two centers between March and May 2020. We included SARS-CoV-2 infected patients of any age and severity. We collected seriated nasopharyngeal swabs and stool samples to detect SARS-CoV-2. After, we performed a systematic review of the prevalence and clearance of SARS-CoV-2 in stools (PROSPERO-ID CRD42020192490). We estimated prevalence using a random-effects model. We assessed clearance time by using Kaplan-Meier curves.RESULTS:
We included 32 patients; mean age was 43.7±17.7 years, 43.8% were female, and 40.6% reported gastrointestinal symptoms. Twenty-five percent (8/32) of patients had detectable viral RNA in stools. The median clearance time in stools of the cohort was 11[10-15] days. Systematic review included 30 studies (1392 patients) with stool samples. Six studies were performed in children and 55% were male. The pooled prevalence of viral detection in stools was 34.6% (twenty-four studies, 1393 patients; 95%CI25.4-45.1); heterogeneity was high (I291.2%, Q208.6; p≤0.001). A meta-regression demonstrates an association between female-gender and lower presence in stools (p=0.004). The median clearance time in stools was 22 days (nineteen studies, 140 patients; 95%CI19-25). After 34 days, 19.9% (95%CI11.3-29.7) of patients have a persistent detection in stools.CONCLUSIONS:
Detection of SARS-CoV-2 in stools is a frequent finding. The clearance of SARS-CoV-2 in stools is prolonged and it takes longer than nasopharyngeal secretions.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
/
Spanish
Journal:
Gastroenterol Hepatol
Year:
2022
Document Type:
Article
Affiliation country:
J.gastrohep.2021.12.009
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