[Interaction between SARS-CoV-2 and Host Innate Immunity].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 53(1): 1-6, 2022 Jan.
Article
in Chinese
| MEDLINE | ID: covidwho-1631843
ABSTRACT
Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic since its outbreak in 2019, presenting serious threats to public health and the health of the people. As one of the main components of the host innate immune system, type-â
interferon (IFN) plays a critical role in the defense against viral infections. The battle between the virus and the host innate immune system determines the disease progression. It has been reported that SARS-CoV-2 inhibits IFN production and suppresses the activation of IFN signaling pathway through its interactions with the host innate immune system. Then, the weakened or delayed response of type-â
interferon causes the disturbance of host immune responses, which is one of the important reasons why SARS-CoV-2 causes such high morbidity and mortality. Herein, we reviewed and discussed the interaction between SARS-CoV-2 viral proteins and the host innate immune system, especially the interaction with type-â
IFN pathway, to provide new insights into the mechanisms of viral evasion of host immune response and new perspectives and strategies for treating COVID-19 with IFN.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interferon Type I
/
COVID-19
Limits:
Humans
Language:
Chinese
Journal:
Sichuan Da Xue Xue Bao Yi Xue Ban
Year:
2022
Document Type:
Article
Affiliation country:
20220160101
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