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Very low levels of remdesivir resistance in SARS-COV-2 genomes after 18 months of massive usage during the COVID19 pandemic: A GISAID exploratory analysis.
Focosi, Daniele; Maggi, Fabrizio; McConnell, Scott; Casadevall, Arturo.
  • Focosi D; North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy. Electronic address: daniele.focosi@gmail.com.
  • Maggi F; Department of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST Sette Laghi, Varese, Italy. Electronic address: fabrizio.maggi63@gmail.com.
  • McConnell S; Department of Medicine, Johns Hopkins School of Public Health and School of Medicine, Baltimore, MD, USA. Electronic address: smcconn8@jhu.edu.
  • Casadevall A; Department of Medicine, Johns Hopkins School of Public Health and School of Medicine, Baltimore, MD, USA. Electronic address: acasade1@jhu.edu.
Antiviral Res ; 198: 105247, 2022 02.
Article in English | MEDLINE | ID: covidwho-1632314
ABSTRACT
Massive usage of antiviral compounds during a pandemic creates an ideal ground for emergence of resistant strains. Remdesivir, a broad-spectrum inhibitor of the viral RNA-dependent RNA polymerase (RdRp), was extensively prescribed under emergency use authorization during the first 18 months of the COVID19 pandemic, before randomized controlled trials showed poor efficacy in hospitalized patients. RdRp mutations conferring resistance to remdesivir are well known from in vitro studies, and the huge SARS-CoV-2 sequencing effort during the ongoing COVID19 pandemic represents an unprecedented opportunity to assess emergence and fitness of antiviral resistance in vivo. We mined the GISAID database to extrapolate the frequency of remdesivir escape mutations. Our analysis reveals very low levels of remdesivir resistance worldwide despite massive usage.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Adenosine Monophosphate / Drug Resistance, Viral / Alanine / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal: Antiviral Res Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Adenosine Monophosphate / Drug Resistance, Viral / Alanine / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal: Antiviral Res Year: 2022 Document Type: Article