Regulation of ER-derived membrane dynamics by the DedA domain-containing proteins VMP1 and TMEM41B.
EMBO Rep
; 23(2): e53894, 2022 02 03.
Article
in English
| MEDLINE | ID: covidwho-1633030
ABSTRACT
The endoplasmic reticulum (ER) is a central hub for the biogenesis of various organelles and lipid-containing structures. Recent studies suggest that vacuole membrane protein 1 (VMP1) and transmembrane protein 41B (TMEM41B), multispanning ER membrane proteins, regulate the formation of many of these ER-derived structures, including autophagosomes, lipid droplets, lipoproteins, and double-membrane structures for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication. VMP1 and TMEM41B possess a DedA domain that is widely distributed not only in eukaryotes but also in prokaryotes and predicted to adopt a characteristic structure containing two reentrant loops. Furthermore, recent studies show that both proteins have lipid scrambling activity. Based on these findings, the potential roles of VMP1 and TMEM41B in the dynamic remodeling of ER membranes and the biogenesis of ER-derived structures are discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Autophagy
/
Membrane Proteins
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
EMBO Rep
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
Embr.202153894
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