The impact of lymphoid memory cells in different ages of COVID-19 patients.
Gene Rep
; 26: 101503, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1633545
ABSTRACT
Coronaviruses are highly pathogenic and transmissible viruses. The SARS-CoV-2 virus that emerged in December 2019 is increasingly recognized as a serious, worldwide public health concern. Respiratory infections and the hyper-inflammatory response induced by SARS-CoV-2 play a key role in disease severity and death in infected COVID-19 patients. However, much uncertainty still exists about the pathogenesis and various effects of COVID-19 on immune system. It seems that memory T cells can reduce the severity of COVID-19 infection by inducing a protective immune response. Memory T cells along with protective antibodies are the main defenses and also protective barrier against recurrent COVID-19 infection. The role of Memory T cells varies in different ages and the severity of COVID-19 infection varies between children, adults and the elderly. Furthermore, the aim of this review is to evaluate the role of memory cells in mild, moderate and severe infected COVID-19 patients with different ages.
ACE2, angiotensin-converting enzyme 2; BALF, broncho-alveolar fluid; CCL, CC-chemokine ligand; CNS, central nervous system; COVID-19; COVID-19, coronavirus disease-19; CRP, C-reactive protein; CRS, cytokine release syndrome; CXCL, CXC-chemokine ligand; EDTA, ethylenediaminetetraacetic acid; ICU, intensive care unit; MNPs, mononuclear phagocytes; Memory B cells; Memory T cells; NK, natural killer (NK) cells; SARS-CoV-2; TNF, tumor necrosis factor; aging
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
Gene Rep
Year:
2022
Document Type:
Article
Affiliation country:
J.GENREP.2022.101503
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