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Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry.
Kamrath, Clemens; Rosenbauer, Joachim; Eckert, Alexander J; Siedler, Kai; Bartelt, Heike; Klose, Daniela; Sindichakis, Marina; Herrlinger, Silke; Lahn, Valentina; Holl, Reinhard W.
  • Kamrath C; Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany.
  • Rosenbauer J; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.
  • Eckert AJ; German Center for Diabetes Research, Munich-Neuherberg, Germany.
  • Siedler K; German Center for Diabetes Research, Munich-Neuherberg, Germany.
  • Bartelt H; Institute of Epidemiology and Medical Biometry, Central Institute of Biomedical Technology, Ulm University, Ulm, Germany.
  • Klose D; Hospital for Children and Adolescents, Helios Clinics Pforzheim, Pforzheim, Germany.
  • Sindichakis M; Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
  • Herrlinger S; University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Lahn V; Hospital for Children and Adolescents, Klinikum Traunstein, Traunstein, Germany.
  • Holl RW; Professor Hess Parent-Child Center, Bremen Central Clinic, Bremen, Germany.
Diabetes Care ; 45(8): 1762-1771, 2022 08 01.
Article in English | MEDLINE | ID: covidwho-1633803
ABSTRACT

OBJECTIVE:

The aim of this study was to investigate the incidence of type 1 diabetes in children and adolescents during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with previous years. RESEARCH DESIGN AND

METHODS:

Based on data from the multicenter German Diabetes Prospective Follow-up Registry, we analyzed the incidence of type 1 diabetes per 100,000 patient-years in children and adolescents from 1 January 2020 through 30 June 2021. Using Poisson regression models, expected incidences for 2020/21 were estimated based on the data from 2011 to 2019 and compared with observed incidences in 2020/21 by estimating incidence rate ratios (IRRs) with 95% CIs.

RESULTS:

From 1 January 2020 to 30 June 2021, 5,162 children and adolescents with new-onset type 1 diabetes in Germany were registered. The observed incidence in 2020/21 was significantly higher than the expected incidence (24.4 [95% CI 23.6-25.2] vs. 21.2 [20.5-21.9]; IRR 1.15 [1.10-1.20]; P < 0.001). IRRs were significantly elevated in June 2020 (IRR 1.43 [1.07-1.90]; P = 0.003), July 2020 (IRR 1.48 [1.12-1.96]; P < 0.001), March 2021 (IRR 1.29 [1.01-1.65]; P = 0.028), and June 2021 (IRR 1.39 [1.04-1.85]; P = 0.010).

CONCLUSIONS:

A significant increase in the incidence of type 1 diabetes in children was observed during the COVID-19 pandemic, with a delay in the peak incidence of type 1 diabetes by ∼3 months after the peak COVID-19 incidence and also after pandemic containment measures. The underlying causes are yet unknown. However, indirect rather than direct effects of the pandemic are more likely to be the cause.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 1 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adolescent / Child / Humans Country/Region as subject: Europa Language: English Journal: Diabetes Care Year: 2022 Document Type: Article Affiliation country: Dc21-0969

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 1 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adolescent / Child / Humans Country/Region as subject: Europa Language: English Journal: Diabetes Care Year: 2022 Document Type: Article Affiliation country: Dc21-0969