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Elucidating symptoms of COVID-19 illness in the Arizona CoVHORT: a longitudinal cohort study.
Khan, Sana M; Farland, Leslie V; Catalfamo, Collin J; Austhof, Erika; Bell, Melanie L; Chen, Zhao; Cordova-Marks, Felina; Ernst, Kacey C; Garcia-Filion, Pamela; Heslin, Kelly M; Hoskinson, Joshua; Jehn, Megan L; Joseph, Emily C S; Kelley, Connor P; Klimentidis, Yann; Russo Carroll, Stephanie; Kohler, Lindsay N; Pogreba-Brown, Kristen; Jacobs, Elizabeth T.
  • Khan SM; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA sanakhan@email.arizona.edu.
  • Farland LV; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Catalfamo CJ; The University of Arizona Cancer Center, Tucson, Arizona, USA.
  • Austhof E; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Bell ML; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Chen Z; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Cordova-Marks F; The University of Arizona Cancer Center, Tucson, Arizona, USA.
  • Ernst KC; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Garcia-Filion P; The University of Arizona Cancer Center, Tucson, Arizona, USA.
  • Heslin KM; Department of Health Promotion Sciences, The University of Arizona, Tucson, Arizona, USA.
  • Hoskinson J; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Jehn ML; Department of Biomedical Informatics, The University of Arizona, Tucson, Arizona, USA.
  • Joseph ECS; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Kelley CP; The University of Arizona Cancer Center, Tucson, Arizona, USA.
  • Klimentidis Y; School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, USA.
  • Russo Carroll S; The University of Arizona Cancer Center, Tucson, Arizona, USA.
  • Kohler LN; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Pogreba-Brown K; Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, Arizona, USA.
  • Jacobs ET; Department of Community, Environment, and Policy, The University of Arizona, Tucson, Arizona, USA.
BMJ Open ; 12(1): e053403, 2022 01 17.
Article in English | MEDLINE | ID: covidwho-1633982
ABSTRACT

OBJECTIVE:

To elucidate the symptoms of laboratory-confirmed COVID-19 cases as compared with laboratory-confirmed negative individuals and to the untested general population among all participants who reported symptoms within a large prospective cohort study. SETTING AND

DESIGN:

This work was conducted within the framework of the Arizona CoVHORT, a longitudinal prospective cohort study conducted among Arizona residents.

PARTICIPANTS:

Eligible participants were any individual living in Arizona and were recruited from across Arizona via COVID-19 case investigations, participation in testing studies and a postcard mailing effort. PRIMARY AND SECONDARY OUTCOME

MEASURES:

The primary outcome measure was a comparison of the type and frequency of symptoms between COVID-19-positive cases, tested but negative individuals and the general untested population who reported experiencing symptoms consistent with COVID-19.

RESULTS:

Of the 1335 laboratory-confirmed COVID-19 cases, 180 (13.5%) reported having no symptoms. Of those that did report symptoms, the most commonly reported were fatigue (82.2%), headache (74.6%), aches, pains or sore muscles (66.3%), loss of taste or smell (62.8) and cough (61.9%). In adjusted logistic regression models, COVID-19-positive participants were more likely than negative participants to experience loss of taste and smell (OR 12.1; 95% CI 9.6 to 15.2), bone or nerve pain (OR 3.0; 95% CI 2.2 to 4.1), headache (OR 2.6; 95% CI 2.2 to 3.2), nausea (OR 2.4; 95% CI 1.9 to 3.1) or diarrhoea (OR 2.1; 95% CI 1.7 to 2.6). Fatigue (82.9) and headache (74.9) had the highest sensitivities among symptoms, while loss of taste or smell (87.2) and bone or nerve pain (92.9) had the high specificities among significant symptoms associated with COVID-19.

CONCLUSION:

When comparing confirmed COVID-19 cases with either confirmed negative or untested participants, the pattern of symptoms that discriminates SARS-CoV-2 infection from those arising from other potential circulating pathogens may differ from general reports of symptoms among cases alone.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: BMJOPEN-2021-053403

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: BMJOPEN-2021-053403