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K63 ubiquitination in immune signaling.
Madiraju, Charitha; Novack, Jeffrey P; Reed, John C; Matsuzawa, Shu-Ichi.
  • Madiraju C; Marshall B. Ketchum University, Fullerton, CA, USA.
  • Novack JP; Pacific Northwest University of Health Sciences, Yakima, WA, USA.
  • Reed JC; Sanofi, Paris, France & University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA. Electronic address: John.Reed@sanofi.com.
  • Matsuzawa SI; Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: smatsuza@kuhp.kyoto-u.ac.jp.
Trends Immunol ; 43(2): 148-162, 2022 02.
Article in English | MEDLINE | ID: covidwho-1634995
ABSTRACT
Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent evidence has shown that the control of multiple immune functions, including chronic inflammation, pathogen responses, lymphocyte activation, and regulatory signaling, is altered by K63 ubiquitination. In this review, we detail the novel cellular sensors that are dependent on K63 ubiquitination for their function in the immune signaling network. Many pathogens, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can target K63 ubiquitination to inhibit pathogen immune responses; we describe novel details of the pathways involved and summarize recent clinically relevant SARS-CoV-2-specific responses. We also discuss recent evidence that regulatory T cell (Treg) versus T helper (TH) 1 and TH17 cell subset regulation might involve K63 ubiquitination. Knowledge gaps that merit future investigation and clinically relevant pathways are also addressed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lysine Type of study: Prognostic study Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.it.2021.12.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lysine Type of study: Prognostic study Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.it.2021.12.005