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Evaluating COVID-19 Associated Coagulopathy with Thromboelastogram-Experience from South India
Indian Journal of Hematology and Blood Transfusion ; 37(SUPPL 1):S146-S147, 2021.
Article in English | EMBASE | ID: covidwho-1635559
ABSTRACT

Introduction:

Coagulopathy in COVID-19 progresses from initialpulmonary microthrombi without systemic coagulation activation to asystemic hypercoagulable stage with widespread activation of coagulation and then to a hypocoagulable picture seen in later phases ofthe disease.Aims &

Objectives:

We decided to conduct this study because of thesevere infections in 2021 compared to 2020 to understand theCoagulopathy in COVID-19 among our population using Thromboelastography (TEG) and V curve.Materials &

Methods:

All adult patients with a confirmed COVID-19 and TEG report were recruited in the study and followed up fortwo months. Citrated Kaolin TEG parameters included were R and Ktime, alpha angle, maximum amplitude, clotting index, lysis 30. Thefirst-degree velocity curve of (V curve) TEG which extrapolatesthrombin generation potential with maximum rate of thrombin generation and time as well as thrombin generated. Comparison betweensurvivors and thromboembolisms were made with TEG parameters.

Result:

Study included 43 patients after excluding three patients.Average age was 58.34 (± 15.35) and majority of them were males(34/43). TEG as well as V-curve were hypercoagulable compared toage matched reference range. Systemic hypercoagulable stage (34/43)and interestingly 13/34 patients had secondary fibrinolysis activity.Mortality rate and thrombotic incidents was 32.56% and 30.23%respectively. Risk factors for mortality were MA, LY 30, TG,Hypercoagulable TEG (OR-7.36), D Dimer (OR-1.40) and Thrombosis (OR-1.37). Incidents of Thrombosis in decreasing order wasacute coronary syndrome (n = 10), DVT with PTE (n = 2) and MCAinfarction (n-1). LY 30 was associated with an increased thromboticrisk (OR-15.3, r = 0.122, Correlation-0.40, P = 0.02). Repeat TEGwas performed in 11 patients which was consistent with a hypercoagulable picture even after 5 days of thromboprophylaxis.

Conclusions:

TEG is useful in diagnosing and categorizing Coagulopathy associated with COVID-19.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: English Journal: Indian Journal of Hematology and Blood Transfusion Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: English Journal: Indian Journal of Hematology and Blood Transfusion Year: 2021 Document Type: Article