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Potential metal-related strategies for prevention and treatment of COVID-19.
Ni, Ya-Qiong; Zeng, Hui-Hui; Song, Xian-Wen; Zheng, Jun; Wu, Hui-Qiong; Liu, Chun-Tai; Zhang, Yi.
  • Ni YQ; Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083 China.
  • Zeng HH; Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083 China.
  • Song XW; Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083 China.
  • Zheng J; Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083 China.
  • Wu HQ; Hanshan Normal University, Chaozhou, 521041 China.
  • Liu CT; College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518071 China.
  • Zhang Y; Key Laboratory of Materials Processing and Mold (Zhengzhou University), Ministry of Education, Zhengzhou, 450002 China.
Rare Metals ; 41(4): 1129-1141, 2022.
Article in English | MEDLINE | ID: covidwho-1635959
ABSTRACT
Abstract The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed severe threats to human health, public safety, and the global economy. Metal nutrient elements can directly or indirectly take part in human immune responses, and metal-related drugs have served as antiviral drugs and/or enzyme inhibitors for many years, providing potential solutions to the prevention and treatment of COVID-19. Metal-based drugs are currently under a variety of chemical structures and exhibit wide-range bioactivities, demonstrating irreplaceable advantages in pharmacology. This review is an intention to summarize recent progress in the prevention and treatment strategies against COVID-19 from the perspective of metal pharmacology. The current and potential utilization of metal-based drugs is briefly introduced. Specifically, metallohydrogels that have been shown to present superior antiviral activities are stressed in the paper as potential drugs for the treatment of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Rare Metals Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Rare Metals Year: 2022 Document Type: Article