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Anticoagulation Prior to COVID-19 Infection Has No Impact on 6 Months Mortality: A Propensity Score-Matched Cohort Study.
Protasiewicz, Marcin; Reszka, Konrad; Kosowski, Wojciech; Adamik, Barbara; Bombala, Wojciech; Doroszko, Adrian; Gajecki, Damian; Gawrys, Jakub; Guzinski, Maciej; Jedrzejczyk, Maria; Kaliszewski, Krzysztof; Kilis-Pstrusinska, Katarzyna; Konopska, Boguslawa; Kopec, Agnieszka; Kujawa, Krzysztof; Langner, Anna; Larysz, Anna; Lis, Weronika; Pawlik-Sobecka, Lilla; Gorka-Dynysiewicz, Joanna; Rosiek-Biegus, Marta; Matera-Witkiewicz, Agnieszka; Matys, Tomasz; Pomorski, Michal; Sokolski, Mateusz; Sokolowski, Janusz; Tomasiewicz-Zapolska, Anna; Madziarska, Katarzyna; Jankowska, Ewa A.
  • Protasiewicz M; Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Reszka K; Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland.
  • Kosowski W; Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland.
  • Adamik B; Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Bombala W; Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland.
  • Doroszko A; Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Gajecki D; Statistical Analysis Centre, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Gawrys J; Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Guzinski M; Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Jedrzejczyk M; Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Kaliszewski K; Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Kilis-Pstrusinska K; Department of Nursing and Obstetrics, Division of Internal Medicine Nursing, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Konopska B; Clinical Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Kopec A; Clinical Department of Paediatric Nephrology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Kujawa K; Department of Pharmaceutical Biochemistry, Division of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Langner A; Clinical Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Larysz A; Statistical Analysis Centre, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Lis W; Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Pawlik-Sobecka L; Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland.
  • Gorka-Dynysiewicz J; Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland.
  • Rosiek-Biegus M; Clinical Department of Heart Transplantation and Mechanical Circulatory Support, Institute of Heart Disease, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Matera-Witkiewicz A; Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland.
  • Matys T; Division of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Pomorski M; Department of Pharmaceutical Biochemistry, Division of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Sokolski M; Clinical Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Sokolowski J; Screening of Biological Activity Assays and Collection of Biological Material Lab., Wroclaw Medical University Biobank, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Tomasiewicz-Zapolska A; Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Madziarska K; 2nd Department of Gynaecology and Obstetrics, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Jankowska EA; Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
J Clin Med ; 11(2)2022 Jan 12.
Article in English | MEDLINE | ID: covidwho-1636656
ABSTRACT
The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior to COVID-19 infection may impact clinical profile, as well as mortality rate among patients hospitalized with COVID-19. The study was based on retrospective analysis of medical records of patients with laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group of 236 patients receiving any anticoagulant treatment prior to COVID-19 infection (AT group) was compared to 236 patients without previous anticoagulation (no AT group). In 180 days, the observation we noted comparable mortality rate in AT and no AT groups (38.5% vs. 41.1%, p = 0.51). Similarly, we did not observe any statistically significant differences in admission in the intensive care unit (14.1% vs. 9.6%, p = 0.20), intubation and mechanical ventilation (15.0% vs. 11.6%, p = 0.38), catecholamines usage (14.3% vs. 13.8%, p = 0.86), and bleeding rate (6.3% vs. 8.9%, p = 0.37) in both groups. Our results suggest that antithrombotic treatment prior to COVID-19 infection is unlikely to be protective for morbidity and mortality in patients hospitalized with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11020352

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11020352