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Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy.
Rando, Emanuele; Segala, Francesco Vladimiro; Vargas, Joel; Seguiti, Cristina; De Pascale, Gennaro; Murri, Rita; Fantoni, Massimo.
  • Rando E; Clinic of Infectious Diseases, Catholic University of the Sacred Heart, 00168 Rome, Italy.
  • Segala FV; Clinic of Infectious Diseases, Catholic University of the Sacred Heart, 00168 Rome, Italy.
  • Vargas J; Department of Laboratory and Infectious Diseases Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
  • Seguiti C; Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
  • De Pascale G; Clinic of Infectious Diseases, Catholic University of the Sacred Heart, 00168 Rome, Italy.
  • Murri R; Department of Laboratory and Infectious Diseases Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
  • Fantoni M; Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Antibiotics (Basel) ; 11(1)2021 Dec 21.
Article in English | MEDLINE | ID: covidwho-1636790
ABSTRACT
Cefiderocol use in A. baumannii pneumonia still represents an important matter of debate. The aim of this study is to describe 13 cases of carbapenem-resistant A. baumannii (CRAB) pneumonia treated with cefiderocol in real-life practice. We retrospectively included patients with CRAB pneumonia hospitalized at Fondazione Policlinico Universitario Agostino Gemelli Hospital treated with cefiderocol either in the general ward or the intensive care unit. A total of 11 patients out of 13 had ventilator-associated pneumonia caused by CRAB, and 12/13 patients had polymicrobial infection. We found a 30-day success rate of 54%. Cefiderocol may have a role when facing severe XDR A. baumannii pneumonia. Future studies are warranted to better define its place in therapy in CRAB infections.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2021 Document Type: Article Affiliation country: Antibiotics11010003

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2021 Document Type: Article Affiliation country: Antibiotics11010003