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[COVID-19 related stroke]. / Insul't, assotsiirovannyi s COVID-19.
Shchukin, I A; Fidler, M S; Koltsov, I A; Suvorov, A Yu.
  • Shchukin IA; Pirogov Russian National Research Medical University, Moscow, Russia.
  • Fidler MS; Pirogov Russian National Research Medical University, Moscow, Russia.
  • Koltsov IA; Pirogov Russian National Research Medical University, Moscow, Russia.
  • Suvorov AY; Federal Center of Brain and Neurotechnologies, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova ; 121(12. Vyp. 2): 69-76, 2021.
Article in Russian | MEDLINE | ID: covidwho-1637642
ABSTRACT
The COVID-19 pandemic had a significant impact on both the incidence of acute cerebral circulatory disorders and the structure of mortality. SARS-CoV-2 increases the risk of both ischemic and hemorrhagic stroke. The key pathogenetic links underlying the development of cerebral stroke in COVID-19 are impaired functioning of angiotensin 2 receptors, accompanied by the accumulation of excess angiotensin 2, endothelial dysfunction, hypercoagulation, hyperproduction of proinflammatory cytokines and oxidative storm. In patients with stroke and COVID-19, the severity of the lesion is associated with a dual mechanism of ischemia - systemic and cerebral. The possibilities of medical correction of systemic disorders associated with coronavirus infection, as well as local ones caused by ischemic or hemorrhagic brain damage, are limited. Substances with antioxidant activity could potentially be effective in patients with stroke and COVID-1.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: Russian Journal: Zh Nevrol Psikhiatr Im S S Korsakova Journal subject: Neurology / Psychiatry Year: 2021 Document Type: Article Affiliation country: Jnevro202112112269

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: Russian Journal: Zh Nevrol Psikhiatr Im S S Korsakova Journal subject: Neurology / Psychiatry Year: 2021 Document Type: Article Affiliation country: Jnevro202112112269