[COVID-19 related stroke]. / Insul't, assotsiirovannyi s COVID-19.
Zh Nevrol Psikhiatr Im S S Korsakova
; 121(12. Vyp. 2): 69-76, 2021.
Article
in Russian
| MEDLINE | ID: covidwho-1637642
ABSTRACT
The COVID-19 pandemic had a significant impact on both the incidence of acute cerebral circulatory disorders and the structure of mortality. SARS-CoV-2 increases the risk of both ischemic and hemorrhagic stroke. The key pathogenetic links underlying the development of cerebral stroke in COVID-19 are impaired functioning of angiotensin 2 receptors, accompanied by the accumulation of excess angiotensin 2, endothelial dysfunction, hypercoagulation, hyperproduction of proinflammatory cytokines and oxidative storm. In patients with stroke and COVID-19, the severity of the lesion is associated with a dual mechanism of ischemia - systemic and cerebral. The possibilities of medical correction of systemic disorders associated with coronavirus infection, as well as local ones caused by ischemic or hemorrhagic brain damage, are limited. Substances with antioxidant activity could potentially be effective in patients with stroke and COVID-1.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Stroke
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Russian
Journal:
Zh Nevrol Psikhiatr Im S S Korsakova
Journal subject:
Neurology
/
Psychiatry
Year:
2021
Document Type:
Article
Affiliation country:
Jnevro202112112269
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