The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.
Nat Genet
; 54(2): 121-124, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1637651
ABSTRACT
Using online surveys, we collected data regarding COVID-19-related loss of smell or taste from 69,841 individuals. We performed a multi-ancestry genome-wide association study and identified a genome-wide significant locus in the vicinity of the UGT2A1 and UGT2A2 genes. Both genes are expressed in the olfactory epithelium and play a role in metabolizing odorants. These findings provide a genetic link to the biological mechanisms underlying COVID-19-related loss of smell or taste.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Glucuronosyltransferase
/
Ageusia
/
Genome-Wide Association Study
/
Genetic Loci
/
Anosmia
/
COVID-19
/
UDP-Glucuronosyltransferase 1A9
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Nat Genet
Journal subject:
Genetics, Medical
Year:
2022
Document Type:
Article
Affiliation country:
S41588-021-00986-w
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