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Epidemiologic, Immunologic, and Virus Characteristics in Patients With Paired Severe Acute Respiratory Syndrome Coronavirus 2 Serology and Reverse-Transcription Polymerase Chain Reaction Testing.
Shragai, Talya; Smith-Jeffcoat, Sarah E; Koh, Mitsuki; Schechter, Marcos C; Rebolledo, Paulina A; Kasinathan, Vyjayanti; Wang, Yun; Hoffman, Adam; Miller, Halie; Tejada-Strop, Alexandra; Jain, Shilpi; Tamin, Azaibi; Harcourt, Jennifer L; Thornburg, Natalie J; Wong, Phili; Medrzycki, Magdalena; Folster, Jennifer M; Semenova, Vera; Steward-Clark, Evelene; Drobenuic, Jan; Biedron, Caitlin; Stewart, Rebekah J; da Silva, Juliana; Kirking, Hannah L; Tate, Jacqueline E.
  • Shragai T; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Smith-Jeffcoat SE; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Koh M; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Schechter MC; Emory University, Atlanta, Georgia,USA.
  • Rebolledo PA; Grady Memorial Hospital, Atlanta, Georgia, USA.
  • Kasinathan V; Emory University, Atlanta, Georgia,USA.
  • Wang Y; Emory University, Atlanta, Georgia,USA.
  • Hoffman A; Emory University, Atlanta, Georgia,USA.
  • Miller H; Emory University, Atlanta, Georgia,USA.
  • Tejada-Strop A; Grady Memorial Hospital, Atlanta, Georgia, USA.
  • Jain S; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Tamin A; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Harcourt JL; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Thornburg NJ; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Wong P; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Medrzycki M; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Folster JM; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Semenova V; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Steward-Clark E; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Drobenuic J; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Biedron C; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Stewart RJ; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • da Silva J; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Kirking HL; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
  • Tate JE; Centers for Disease Control and Prevention, Atlanta, Georgia,USA.
J Infect Dis ; 225(2): 229-237, 2022 01 18.
Article in English | MEDLINE | ID: covidwho-1637718
ABSTRACT

BACKGROUND:

The natural history and clinical progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can be better understood using combined serological and reverse-transcription polymerase chain reaction (RT-PCR) testing.

METHODS:

Nasopharyngeal swabs and serum were collected at a single time-point from patients at an urban, public hospital during August-November 2020 and tested for SARS-CoV-2 using RT-PCR, viral culture, and anti-spike pan-immunoglobulin antibody testing. Participant demographics and symptoms were collected through interview. The χ 2 and Fisher exact tests were used to identify associations between RT-PCR and serology results with presence of viable virus and frequency of symptoms.

RESULTS:

Among 592 participants, 129 (21.8%) had evidence of SARS-CoV-2 infection by RT-PCR or serology. Presence of SARS-CoV-2 antibodies was strongly associated with lack of viable virus (P = .016). COVID-19 symptom frequency was similar for patients testing RT-PCR positive/seronegative and patients testing RT-PCR positive/seropositive. Patients testing RT-PCR positive/seronegative reported headaches, fatigue, diarrhea, and vomiting at rates not statistically significantly different from those testing RT-PCR negative/seropositive.

CONCLUSIONS:

While patients testing SARS-CoV-2 seropositive were unlikely to test positive for viable virus and were therefore at low risk for forward transmission, coronavirus disease 2019 (COVID-19) symptoms were common. Paired SARS-CoV-2 RT-PCR and antibody testing provides more nuanced understanding of patients' COVID-19 status.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis