The association of obesity level and inhospital survival of patients with covid-19 who received corticosteroids
Circulation
; 144(SUPPL 1), 2021.
Article
in English
| EMBASE | ID: covidwho-1637879
ABSTRACT
Introduction:
Obesity is one of the most frequent comorbidities among COVID-19 patients. Although previous studies have shown higher body mass index (BMI) is associated with higher mortality, steroids as the current standard treatment for moderate to severe COVID-19 infection were not applied in most patients in these studies.Hypothesis:
We hypothesized that patients with higher BMI still have higher mortality even on steroids.Methods:
We conducted a retrospective study of 4,587 hospitalized patients with COVID-19 who received corticosteroids between March 1 , 2020, and March 30 , 2021. We divided patients into 6 groups by BMI[MOU1] (less 18.5, 18.5-25, 25-30, 30-35, 35-40, 40 or greater, kg/m2 ) and investigated in-hospital mortality as the primary outcome, in-hospital mortality among severe COVID-19 patients which was defined as requiring intensive care unit or endotracheal intubation as a subgroup analysis, and acute kidney injury (AKI) incidence rate as the secondary outcome.Results:
Patients with higher BMI were younger and more likely to have a history of asthma, obstructive sleep apnea, diabetes, and less likely to have malignancies. The smooth spline curve showed J curve association of BMI with risk adjusted in-hospital mortality with flexion point at BMI between 25 and 30 kg/m2 (Figure 1). Compared to overweight (25≤BMI<30 kg/m2 ) patients, class III obesity (BMI>40 kg/m2 ) was associated with higher risk adjusted in-hospital mortality overall (Table 1) as well as among patients with severe COVID-19 (OR [95% CI] 3.21 [1.86-5.66], P<0.001). Class III obesity was also associated with a higher risk adjusted incidence of AKI (OR [95% CI] 1.52 [1.06-2.18], P=0.024) compared to overweight patients.Conclusions:
Class III obesity was associated with higher in-hospital mortality and AKI incidence rate in COVID-19 patients with steroids treatment.
corticosteroid; acute, kidney, failure; adult; asthma; body, mass; cancer, patient; cancer, survival; conference, abstract; controlled, study; coronavirus, disease, 2019; diabetes, mellitus; drug, therapy; endotracheal, intubation; female; hospital, patient; human; in-hospital, mortality; incidence; intensive, care, unit; major, clinical, study; male; malignant, neoplasm; obesity; outcome, assessment; overall, survival; retrospective, study; sleep, disordered, breathing
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Circulation
Year:
2021
Document Type:
Article
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