Physiologic changes of covid-19 infection detected by cardiac implantable electronic device data
Circulation
; 144(SUPPL 1), 2021.
Article
in English
| EMBASE | ID: covidwho-1638539
ABSTRACT
Background:
The trajectory of cardiac physiology throughout a COVID-19 infection remains poorly described. This study aimed to characterize physiologic changes associated with acute COVID-19 infection among patients with cardiac implantable electronic devices (CIEDs).Methods:
The study population included 286 patients with a Boston Scientific CIED across a large health system. CIED sensor data from March 2020-February 2021 were linked to clinical data from electronic health records. Three cohorts were created COVID-positive (n=20), COVID-negative (n=166), and an untested control (n=100) to account for testing bias as institutional protocols only allowed symptomatic patients to be tested in the early months of the study. The magnitude of sensor changes from baseline (30-60 days before a COVID-19 test) to event (15-day window around a test) was compared between cohorts using one-way ANOVA. A date during the study window was randomly selected to serve as the event for control cases.Results:
Comparing COVID-positive vs. COVID-negative vs. control, there was a greater change from baseline to event in respiratory rate (15% vs. 2% vs. 0.6% [p<0.0001]), activity (-44% vs.-12% vs.-6% [p<0.0001]), temperature (1% vs. 0.1% vs.-0.3% [p<0.0001]), and HeartLogic Index, a composite index using multiple sensors (227% vs.-11% vs. 2% [p=0.004]). Average sensor changes show prominent differences surrounding a COVID-19 test for COVID-positive compared to COVIDnegative and control cases (Figure).Conclusions:
Physiologic changes associated with COVID-19 infection are detectable using CIEDs. COVID-positive patients have significant increases in respiratory rate, temperature and HeartLogic index and significant decreases in activity compared to COVID-negative and untested patients. Future studies in a larger population will help characterize the utility of CIEDs in infection surveillance and physiologic worsening that should prompt medical attention.
adult; adverse, device, effect; analysis, of, variance; attention; breathing, rate; cardiac, implantable, electronic, device; cohort, analysis; conference, abstract; controlled, study; COVID-19, testing; device, infection; electronic, health, record; female; human; major, clinical, study; male; Massachusetts; randomized, controlled, trial; sensor
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Circulation
Year:
2021
Document Type:
Article
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