Investigation of COVID-19 infection in subjects with Klinefelter syndrome.
J Endocrinol Invest
; 45(5): 1065-1069, 2022 May.
Article
in English
| MEDLINE | ID: covidwho-1641053
ABSTRACT
PURPOSE:
COVID-19 has worse clinical outcomes in males compared with females and testosterone may determine gender differences. Hypogonadism and supernumerary X chromosome may have a role in the SARS-CoV-2 infection in Klinefelter syndrome (KS). Aim of the study was evaluating COVID-19 frequency and severity in KS.METHODS:
Participants were invited to complete a retrospective self-administered questionnaire containing multiple choice and open-ended answers.RESULTS:
COVID-19 was detected in 10% of the evaluated KS subjects; none was hospitalized. 44.4% of COVID-19 patients had one cohabitant-infected versus 3% of non-infected (p < 0.01). Testosterone levels in infected patients were lower compared to those of non-infected subjects (3.1 ± 1.2 ng/ml vs. 5.2 ± 2 ng/ml, p < 0.05).CONCLUSIONS:
The frequency of SARS-CoV-2 infection among KS subjects was 10%. All infected patients showed mild symptoms. The presence of one affected cohabitant significantly associated with SARS-CoV-2 infection. An association between SARS-CoV-2 and hypogonadism was confirmed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Hypogonadism
/
Klinefelter Syndrome
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
/
Variants
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J Endocrinol Invest
Year:
2022
Document Type:
Article
Affiliation country:
S40618-021-01727-w
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