Your browser doesn't support javascript.
p38 activation and viral infection.
Wang, Luyao; Xia, Zhiqiang; Tang, Wei; Sun, Yu; Wu, Yingliang; Kwok, Hang Fai; Sun, Fang; Cao, Zhijian.
  • Wang L; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan430072, Hubei, China.
  • Xia Z; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan430072, Hubei, China.
  • Tang W; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan430072, Hubei, China.
  • Sun Y; School of Medicine, Wuhan University of Science and Technology, Wuhan430065, Hubei, China.
  • Wu Y; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan430072, Hubei, China.
  • Kwok HF; Frontiers Science Center for Precision Oncology of MoE, University of Macau, Taipa, Macau, China.
  • Sun F; Faculty of Health Sciences, Cancer Center, University of Macau, Avenida de Universidade, Taipa, Macau, China.
  • Cao Z; State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan430072, Hubei, China.
Expert Rev Mol Med ; 24: e4, 2022 01 21.
Article in English | MEDLINE | ID: covidwho-1641781
ABSTRACT
Viruses completely rely on the energy and metabolic systems of host cells for life activities. Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no specific clinical vaccines or drugs against most viral infections. Therefore, understanding the molecular and cellular mechanisms of viral infections is of great significance to prevent and treat viral diseases. A variety of viral infections are related to the p38 MAPK signalling pathway, and p38 is an important host factor in virus-infected cells. Here, we introduce the different signalling pathways of p38 activation and then summarise how different viruses induce p38 phosphorylation. Finally, we provide a general summary of the effect of p38 activation on virus replication. Our review provides integrated data on p38 activation and viral infections and describes the potential application of targeting p38 as an antiviral strategy.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / P38 Mitogen-Activated Protein Kinases Topics: Vaccines Limits: Humans Language: English Journal: Expert Rev Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: Erm.2021.29

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / P38 Mitogen-Activated Protein Kinases Topics: Vaccines Limits: Humans Language: English Journal: Expert Rev Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: Erm.2021.29