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Update on COVID-19 vaccination in pediatric solid organ transplant recipients.
Dulek, Daniel E; Ardura, Monica I; Green, Michael; Michaels, Marian G; Chaudhuri, Abanti; Vasquez, Luciola; Danziger-Isakov, Lara; Posfay-Barbe, Klara M; McCulloch, Mignon I; L'Huillier, Arnaud G; Benden, Christian.
  • Dulek DE; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Ardura MI; Nationwide Children's Hospital & The Ohio State University, Columbus, Ohio, USA.
  • Green M; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Michaels MG; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Chaudhuri A; Stanford University, Palo Alto, California, USA.
  • Vasquez L; Hospital Guillermo Almenara Irigoyen, Lima, Peru.
  • Danziger-Isakov L; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Posfay-Barbe KM; Children's Hospital of Geneva, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
  • McCulloch MI; Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • L'Huillier AG; Children's Hospital of Geneva, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
  • Benden C; University of Zurich Faculty of Medicine, Zurich, Switzerland.
Pediatr Transplant ; 26(5): e14235, 2022 08.
Article in English | MEDLINE | ID: covidwho-1642766
ABSTRACT

BACKGROUND:

COVID-19 vaccination has been successful in decreasing rates of SARS-CoV-2 infection in areas with high vaccine uptake. Cases of breakthrough SARS-CoV-2 infection remain infrequent among immunocompetent vaccine recipients who are protected from severe COVID-19. Robust data demonstrate the safety, immunogenicity, and effectiveness of several COVID-19 vaccine formulations. Importantly, Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine studies have now included children as young as 5 years of age with safety, immunogenicity, and effectiveness data publicly available. In the United States, emergency use authorization by the Federal Drug Administration and approval from the Centers for Disease Control/Advisory Committee on Immunization Practices have been provided for the 5- to 11-year-old age group.

METHODS:

Members of the International Pediatric Transplant Association (IPTA) provide an updated review of current COVID-19 vaccine data with focus on pediatric solid organ transplant (SOT)-specific issues.

RESULTS:

This review provides an overview of current COVID-19 immunogenicity, safety, and efficacy data from key studies, with focus on data of importance to pediatric SOT recipients. Continued paucity of data in the setting of pediatric transplantation remains a challenge.

CONCLUSIONS:

Further studies of COVID-19 vaccination in pediatric SOT recipients are needed to better understand post-vaccine COVID-19 T-cell and antibody kinetics and determine the optimal vaccine schedule. Increased COVID-19 vaccine acceptability, uptake, and worldwide availability are needed to limit the risk that COVID-19 poses to pediatric solid organ transplant recipients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Child / Child, preschool / Humans Language: English Journal: Pediatr Transplant Journal subject: Pediatrics / Transplantation Year: 2022 Document Type: Article Affiliation country: Petr.14235

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Child / Child, preschool / Humans Language: English Journal: Pediatr Transplant Journal subject: Pediatrics / Transplantation Year: 2022 Document Type: Article Affiliation country: Petr.14235