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Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses.
Barre, Annick; Van Damme, Els J M; Klonjkowski, Bernard; Simplicien, Mathias; Sudor, Jan; Benoist, Hervé; Rougé, Pierre.
  • Barre A; UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, France.
  • Van Damme EJM; Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
  • Klonjkowski B; UMR Virologie, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, F-94700 Maisons-Alfort, France.
  • Simplicien M; UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, France.
  • Sudor J; UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, France.
  • Benoist H; UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, France.
  • Rougé P; UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, F-31062 Toulouse, France.
Cells ; 11(3)2022 01 20.
Article in English | MEDLINE | ID: covidwho-1643582
ABSTRACT
Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function the glycan structures contribute to virus protection as well as host cell recognition. The three classical types of N-glycans, in particular complex glycans, high-mannose glycans, and hybrid glycans, together with some O-glycans, participate in the glycan shield of the Ebola virus, influenza virus, human cytomegalovirus, herpes virus, human immunodeficiency virus, Lassa virus, and MERS-CoV, SARS-CoV, and SARS-CoV-2, which are responsible for respiratory syndromes. The glycans are linked to glycoproteins that occur as metastable prefusion glycoproteins on the surface of infectious virions such as gp120 of HIV, hemagglutinin of influenza, or spike proteins of beta-coronaviruses. Plant lectins with different carbohydrate-binding specificities and, especially, mannose-specific lectins from the Vicieae tribe, such as pea lectin and lentil lectin, can be used as glycan probes for targeting the glycan shield because of their specific interaction with the α1,6-fucosylated core Man3GlcNAc2, which predominantly occurs in complex and hybrid glycans. Other plant lectins with Neu5Ac specificity or GalNAc/T/Tn specificity can also serve as potential glycan probes for the often sialylated complex glycans and truncated O-glycans, respectively, which are abundantly distributed in the glycan shield of enveloped viruses. The biomedical and therapeutical potential of plant lectins as antiviral drugs is discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / Plant Lectins / Viral Envelope / SARS-CoV-2 / COVID-19 / Fabaceae Type of study: Observational study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11030339

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polysaccharides / Plant Lectins / Viral Envelope / SARS-CoV-2 / COVID-19 / Fabaceae Type of study: Observational study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11030339