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The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients.
Chen, Yifei; Chen, Liangjun; Deng, Qiaoling; Zhang, Guqin; Wu, Kaisong; Ni, Lan; Yang, Yibin; Liu, Bing; Wang, Wei; Wei, Chaojie; Yang, Jiong; Ye, Guangming; Cheng, Zhenshun.
  • Chen Y; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Chen L; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Deng Q; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Zhang G; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Wu K; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Ni L; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Yang Y; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu B; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Wang W; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Wei C; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Yang J; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Ye G; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Cheng Z; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
J Med Virol ; 92(7): 833-840, 2020 07.
Article in English | MEDLINE | ID: covidwho-164692
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Feces PART_OF Patients
Subject
Feces
Predicate
PART_OF
Object
Patients
3. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
4. Gastrointestinal symptom PROCESS_OF Patients
Subject
Gastrointestinal symptom
Predicate
PROCESS_OF
Object
Patients
5. Patients LOCATION_OF Urine - SpecimenType
Subject
Patients
Predicate
LOCATION_OF
Object
Urine - SpecimenType
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Feces PART_OF Patients
Subject
Feces
Predicate
PART_OF
Object
Patients
8. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
9. Gastrointestinal symptom PROCESS_OF Patients
Subject
Gastrointestinal symptom
Predicate
PROCESS_OF
Object
Patients
10. Patients LOCATION_OF Urine - SpecimenType
Subject
Patients
Predicate
LOCATION_OF
Object
Urine - SpecimenType
ABSTRACT
In December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, and has spread globally. However, the transmission route of SARS-CoV-2 has not been fully understood. In this study, we aimed to investigate SARS-CoV-2 shedding in the excreta of COVID-19 patients. Electronical medical records, including demographics, clinical characteristics, laboratory and radiological findings of enrolled patients were extracted and analyzed. Pharyngeal swab, stool, and urine specimens were collected and tested for SARS-CoV-2 RNA by real-time reverse transcription polymerase chain reaction. Viral shedding at multiple time points in specimens was recorded, and its correlation analyzed with clinical manifestations and the severity of illness. A total of 42 laboratory-confirmed patients were enrolled, 8 (19.05%) of whom had gastrointestinal symptoms. A total of 28 (66.67%) patients tested positive for SARS-CoV-2 RNA in stool specimens, and this was not associated with the presence of gastrointestinal symptoms and the severity of illness. Among them, 18 (64.29%) patients remained positive for viral RNA in the feces after the pharyngeal swabs turned negative. The duration of viral shedding from the feces after negative conversion in pharyngeal swabs was 7 (6-10) days, regardless of COVID-19 severity. The demographics, clinical characteristics, laboratory and radiologic findings did not differ between patients who tested positive and negative for SARS-CoV-2 RNA in the feces. Viral RNA was not detectable in urine specimens from 10 patients. Our results demonstrated the presence of SARS-CoV-2 RNA in the feces of COVID-19 patients and suggested the possibility of SARS-CoV-2 transmission via the fecal-oral route.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / RNA, Viral / Disease Outbreaks / Virus Shedding / Coronavirus Infections / Betacoronavirus Subject: Pneumonia, Viral / RNA, Viral / Disease Outbreaks / Virus Shedding / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Observational study / Risk factors Language: English Journal: J Med Virol Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / RNA, Viral / Disease Outbreaks / Virus Shedding / Coronavirus Infections / Betacoronavirus Subject: Pneumonia, Viral / RNA, Viral / Disease Outbreaks / Virus Shedding / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Observational study / Risk factors Language: English Journal: J Med Virol Year: 2020
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