Influence of oral co-infection on the course of SARS-CoV-2

ABSTRACT

Subject. Currently, the impact of coronavirus on the microbiomes of the mouth, lungs and intestines is not well understood. However, research has been done to alter the intestinal micro-biota of pigs infected with the epidemic swine flu virus. The aim of the study is to identify the relationship between the influence of Co-infection of the oral cavity on the course of SARS-COV2. Material and Methods. Totally 201 patients aged 20 to 87 years, with a confirmed diagnosis on admission International classification of diseases (ICD-X J18.9 coronavirus infection) took part in a clinical study at the Covid Hospital of the Bashkir State Medical University Clinic, Ufa (for 150 beds). The patients were divided into 2 groups with the appearance of co-infection and with the disappearance of co-infection. Results. The results of this study show that patients with co-infection had a severe course of the disease, more often it was necessary to transfer to non-invasive ventilation;the duration of hospitalization increased;required longer treatment and long-term rehabilitation, aimed at normalizing indicators and normalizing microflora. From this, it can be assumed that if there is an infection in the oral cavity, then the severity of the condition and the course of SARS-CoV-2. This means that the risk of co-infection, secondary infection should be taken into account. Conclusions. In conclusion, it should be noted that the state of the immune system un-doubtedly affects the degree of risk of SARS-CoV-2 disease, as well as the severity of the course of this disease.