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American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis.
Cuker, Adam; Tseng, Eric K; Nieuwlaat, Robby; Angchaisuksiri, Pantep; Blair, Clifton; Dane, Kathryn; Davila, Jennifer; DeSancho, Maria T; Diuguid, David; Griffin, Daniel O; Kahn, Susan R; Klok, Frederikus A; Lee, Alfred Ian; Neumann, Ignacio; Pai, Ashok; Righini, Marc; Sanfilippo, Kristen M; Siegal, Deborah; Skara, Mike; Terrell, Deirdra R; Touri, Kamshad; Akl, Elie A; Al Jabiri, Reyad Nayif; Al Jabiri, Yazan Nayif; Barbara, Angela M; Bognanni, Antonio; Bou Akl, Imad; Boulos, Mary; Brignardello-Petersen, Romina; Charide, Rana; Chan, Matthew; Colunga-Lozano, Luis E; Dearness, Karin; Darzi, Andrea J; Hussein, Heba; Karam, Samer G; Kolb, Philipp; Mansour, Razan; Morgano, Gian Paolo; Morsi, Rami Z; Muti-Schünemann, Giovanna; Nadim, Menatalla K; Noori, Atefeh; Philip, Binu A; Piggott, Thomas; Qiu, Yuan; Benitez, Yetiani Roldan; Schünemann, Finn; Stevens, Adrienne; Solo, Karla.
  • Cuker A; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Tseng EK; Division of Hematology/Oncology; St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
  • Nieuwlaat R; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Angchaisuksiri P; Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Blair C; Union, NJ.
  • Dane K; Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD.
  • Davila J; Division of Pediatric Hematology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.
  • DeSancho MT; Oncology, and Cellular Therapies, Division of Hematology-Oncology, Department of Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY.
  • Diuguid D; Coagulation Service, Section of Hematology.
  • Griffin DO; Division of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY.
  • Kahn SR; ProHealth NY, Lake Success, NY.
  • Klok FA; Department of Medicine, McGill University, Montreal, QC, Canada.
  • Lee AI; Division of Thrombosis and Hemostasis, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • Neumann I; Section of Hematology, Yale School of Medicine, New Haven, CT.
  • Pai A; Department of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Righini M; Division of Hematology and Oncology, Kaiser Permanente, Oakland/Richmond, CA.
  • Sanfilippo KM; Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
  • Siegal D; Division of Hematology, Washington University School of Medicine, St. Louis, MO.
  • Skara M; Department of Medicine and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
  • Terrell DR; Cottage Grove, MN.
  • Touri K; Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
  • Akl EA; Toronto, ON, Canada.
  • Al Jabiri RN; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
  • Al Jabiri YN; Department of Medicine, University of Jordan, Amman, Jordan.
  • Barbara AM; Lincoln Medical Center, Bronx, NY.
  • Bognanni A; Department of Health Research Methods, Evidence, and Impact, Health Sciences Centre, McMaster University, Hamilton, ON, Canada.
  • Bou Akl I; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Boulos M; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
  • Brignardello-Petersen R; Department of Health Research Methods, Evidence, and Impact, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
  • Charide R; Department of Health Research Methods, Evidence, and Impact, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
  • Chan M; Clinical Research Institute, American University of Beirut, Beirut, Lebanon.
  • Colunga-Lozano LE; Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Dearness K; Department of Clinical Medicine, Health Science Center, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Darzi AJ; Library Services, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
  • Hussein H; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Karam SG; Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Cairo, Egypt.
  • Kolb P; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Mansour R; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
  • Morgano GP; Office of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan.
  • Morsi RZ; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Muti-Schünemann G; Department of Neurology, University of Chicago, Chicago, IL.
  • Nadim MK; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Noori A; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Philip BA; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Piggott T; The Michael G. DeGroote National Pain Centre, McMaster University, Hamilton, ON, Canada.
  • Qiu Y; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Benitez YR; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Schünemann F; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
  • Stevens A; Michael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
  • Solo K; Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
Blood Adv ; 6(2): 664-671, 2022 01 25.
Article in English | MEDLINE | ID: covidwho-1648275
ABSTRACT

BACKGROUND:

COVID-19-related acute illness is associated with an increased risk of venous thromboembolism (VTE).

OBJECTIVE:

These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for thromboprophylaxis in patients with COVID-19 who do not have confirmed or suspected VTE.

METHODS:

ASH formed a multidisciplinary guideline panel, including 3 patient representatives, and applied strategies to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process, including performing systematic evidence reviews (up to March 2021). The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the grading of recommendations assessment, development, and evaluation (GRADE) approach to assess evidence and make recommendations, which were subject to public comment.

RESULTS:

The panel agreed on 1 additional recommendation. The panel issued a conditional recommendation against the use of outpatient anticoagulant prophylaxis in patients with COVID-19 who are discharged from the hospital and who do not have suspected or confirmed VTE or another indication for anticoagulation.

CONCLUSIONS:

This recommendation was based on very low certainty in the evidence, underscoring the need for high-quality randomized controlled trials assessing the role of postdischarge thromboprophylaxis. Other key research priorities include better evidence on assessing risk of thrombosis and bleeding outcomes in patients with COVID-19 after hospital discharge.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Venous Thromboembolism / COVID-19 / Hematology Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Blood Adv Year: 2022 Document Type: Article Affiliation country: Bloodadvances.2021005945

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Venous Thromboembolism / COVID-19 / Hematology Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Blood Adv Year: 2022 Document Type: Article Affiliation country: Bloodadvances.2021005945