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Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination.
Röltgen, Katharina; Nielsen, Sandra C A; Silva, Oscar; Younes, Sheren F; Zaslavsky, Maxim; Costales, Cristina; Yang, Fan; Wirz, Oliver F; Solis, Daniel; Hoh, Ramona A; Wang, Aihui; Arunachalam, Prabhu S; Colburg, Deana; Zhao, Shuchun; Haraguchi, Emily; Lee, Alexandra S; Shah, Mihir M; Manohar, Monali; Chang, Iris; Gao, Fei; Mallajosyula, Vamsee; Li, Chunfeng; Liu, James; Shoura, Massa J; Sindher, Sayantani B; Parsons, Ella; Dashdorj, Naranjargal J; Dashdorj, Naranbaatar D; Monroe, Robert; Serrano, Geidy E; Beach, Thomas G; Chinthrajah, R Sharon; Charville, Gregory W; Wilbur, James L; Wohlstadter, Jacob N; Davis, Mark M; Pulendran, Bali; Troxell, Megan L; Sigal, George B; Natkunam, Yasodha; Pinsky, Benjamin A; Nadeau, Kari C; Boyd, Scott D.
  • Röltgen K; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Nielsen SCA; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Silva O; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Younes SF; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Zaslavsky M; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Costales C; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Yang F; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Wirz OF; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Solis D; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Hoh RA; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Wang A; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Colburg D; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Zhao S; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Haraguchi E; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Lee AS; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA.
  • Shah MM; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA.
  • Manohar M; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA.
  • Chang I; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA.
  • Gao F; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Mallajosyula V; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Li C; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Liu J; Stanford Health Library, Stanford, CA, USA.
  • Shoura MJ; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Sindher SB; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA.
  • Parsons E; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA.
  • Dashdorj NJ; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Dashdorj ND; Onom Foundation, Ulaanbaatar 17013, Mongolia.
  • Monroe R; Advanced Cell Diagnostics, Newark, CA, USA.
  • Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, USA.
  • Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA.
  • Chinthrajah RS; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA.
  • Charville GW; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Wilbur JL; Meso Scale Diagnostics LLC, Rockville, MD, USA.
  • Wohlstadter JN; Meso Scale Diagnostics LLC, Rockville, MD, USA.
  • Davis MM; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
  • Pulendran B; Department of Pathology, Stanford University, Stanford, CA, USA; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
  • Troxell ML; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Sigal GB; Meso Scale Diagnostics LLC, Rockville, MD, USA.
  • Natkunam Y; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Pinsky BA; Department of Pathology, Stanford University, Stanford, CA, USA; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
  • Nadeau KC; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA.
  • Boyd SD; Department of Pathology, Stanford University, Stanford, CA, USA; Sean N. Parker Center for Allergy & Asthma Research, Stanford University, Stanford, CA, USA. Electronic address: publications_scott_boyd@stanford.edu.
Cell ; 185(6): 1025-1040.e14, 2022 03 17.
Article in English | MEDLINE | ID: covidwho-1649487
ABSTRACT
During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines. We analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences. Antibody breadth against viral variants is lower after infection compared with all vaccines evaluated but improves over several months. Viral variant infection elicits variant-specific antibodies, but prior mRNA vaccination imprints serological responses toward Wuhan-Hu-1 rather than variant antigens. In contrast to disrupted germinal centers (GCs) in lymph nodes during infection, mRNA vaccination stimulates robust GCs containing vaccine mRNA and spike antigen up to 8 weeks postvaccination in some cases. SARS-CoV-2 antibody specificity, breadth, and maturation are affected by imprinting from exposure history and distinct histological and antigenic contexts in infection compared with vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Germinal Center / COVID-19 / BNT162 Vaccine / Antibodies, Viral Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Year: 2022 Document Type: Article Affiliation country: J.cell.2022.01.018

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Germinal Center / COVID-19 / BNT162 Vaccine / Antibodies, Viral Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Year: 2022 Document Type: Article Affiliation country: J.cell.2022.01.018